NCT04106570: PLANEUROB

Neuromuscular Plasticity in Response to Obesity: Effects of Mechanical Overload, Metabolic Disorders and Age

Terminated NA Last updated 18 October 2023

What this trial tests

NA trial testing fatiguability of the knee extensors in Obesity in 92 participants. Terminated before completion.

Timeline

2 December 2019

Primary endpoint
26 June 2023

26 June 2023

Quick facts

Lead sponsor	University Hospital, Clermont-Ferrand
Phase	NA
Status	Terminated
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	other
Enrollment	92
Start date	2 December 2019
Primary completion	26 June 2023
Estimated completion	26 June 2023
Sites	1 location across France

Drugs / interventions tested

• fatiguability of the knee extensors

Conditions studied

• Obesity — all drugs for Obesity →

Sponsor

University Hospital, Clermont-Ferrand

Who can join

Adults 20 to 70, any sex, with Obesity. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Obese people suffer from significant functional limitations, which affect their quality of life and limit their physical activity level. Functional abilities are largely determined by neuromuscular properties, i.e the ability to produce a torque or a power, and fatigability, i.e the ability to maintain a high level of torque production during repeated contractions. Our previous studies on "healthy" obese adolescents (i.e without inflammation or metabolic disorder) suggests that obesity has positive effects on the neural and muscular factors responsible for torque production, with chronic overload acting as a strength training . However, this high torque level is associated with higher fatigability. These results are in contrast with the data obtained on adult obese patients (young and elderly), in whom torque production and fatigability appear to be more impaired, probably due to the development of metabolic disorders associated with obesity (inflammation, insulin resistance and lipid infiltration in muscle) and aging. The respective effects of mechanical overload, metabolic disorders (insulin resistance and lipid infiltration) and aging on neural and muscular factors of torque production and neuromuscular fatigue etiology are not currently known in young adult obese of elderly. Their relationship to the clinical symptoms of mobility troubles is also unknown. However, this knowledge is crucial for designing physical activity programs tailored and adapted to the level of metabolic impairment and age of obese patients. The hypothesis is that mechanical overload associated with obesity has positive effects on torque production in the absence of metabolic alteration and the effect of aging but negative effects on fatigability, mainly due to muscular factors; the insulin resistance increases peripheral fatigue (due to an alteration in the excitability of the sarcolemma during fatiguing exercise), central fatigue, and slows recovery; the development of inflammation and lipid infiltration, which are more pronounced in obese subjects, further affect torque production through inhibition of the nervous control and alteration of contractile properties and muscle architecture, all these phenomena leading to a decrease in torque production and increased fatigability, cumulating with the effects of the ageing (sarcopenia).

Publications & conference data

No peer-reviewed publications indexed yet for this trial.