NCT04106453 is a NA clinical trial of navigated microwave ablation in Liver Cancer, sponsored by Universitätsklinikum Köln.

Who is sponsoring NCT04106453?

NCT04106453 is sponsored by Universitätsklinikum Köln.

What drugs are being tested in NCT04106453?

Interventions in NCT04106453: navigated microwave ablation, ultrasound guided navigation.

What condition does NCT04106453 study?

NCT04106453 studies Liver Cancer, Surgery, Navigation, Spatial.

Is NCT04106453 still recruiting?

NCT04106453 is currently completed. Last updated 5 February 2020.

Last reviewed 2020-02-05 · How we verify

NCT04106453

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Navigated Laparoscopic Microwave Ablation of Tumor Mimics in Pig Liver - an Ex-vivo Trial

Completed NA Last updated 5 February 2020

What this trial tests

NA trial testing navigated microwave ablation in Liver Cancer in 4 participants. Completed in 4 February 2020.

Timeline

14 September 2019

Primary endpoint
14 January 2020

4 February 2020

Quick facts

Lead sponsor	Universitätsklinikum Köln
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	other
Enrollment	4
Start date	14 September 2019
Primary completion	14 January 2020
Estimated completion	4 February 2020
Sites	1 location across Germany

Drugs / interventions tested

navigated microwave ablation
ultrasound guided navigation

Conditions studied

Liver Cancer — all drugs for Liver Cancer →
Surgery — all drugs for Surgery →
Navigation, Spatial — all drugs for Navigation, Spatial →

Sponsor

Universitätsklinikum Köln — full company profile →

Who can join

Eligibility, any sex, with Liver Cancer or Surgery. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In primary and secondary liver tumors microwave ablation could be an alternative to surgical resection.It could be performed laparoscopically. Under ultrasound control the microwave device is placed in the tumor.Therefore spatial orientation is challenging: the tumor is often missed and the failure rate is high. During learning curve this could lead to incomplete tumor ablation and high rate of local recurrence. Targeting systems could optimize that. The CasOne-SPOT-system is an innovative electromagnetic tracking and navigation system for laparoscopic microwave ablation. In this study targeting precision using the SPOT-System should be compared to conventional laparoscopic ultrasound-guided microwave ablation. Therefore tumor mimics (1-2cm) will be created in ex-vivo pig livers and microwave ablation will be performed ultrasound guided or ultrasound navigated. The ablation procedures will be performed by two novices and two experienced surgeons. Aim of this trial is to is to evaluate, if laparoscopic microwave ablation could be facilitated by the use of the SPOT-navigation system.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Navigated laparoscopic microwave ablation of tumour mimics in pig livers: a randomized ex-vivo experimental trial.
Thomas MN, Dieplinger G, Datta RR, Kleinert R, et al · · 2021 · cited 1× · PMID 33289054 · DOI 10.1007/s00464-020-08180-5

Verify or expand the search:

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Other Universitätsklinikum Köln trials

Trials by the same sponsor.

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NCT06388382 — Investigation of the Audible ICD Alert Tone · recruiting
NCT05713708 — S-ICD Electrode Registry · unknown
NCT06063811 — Ventricular Tachycardia Ablation in LVAD Patients · unknown
NCT05389241 — Laparoscopic Augmented Reality for Identification of Liver Lesions - a Pre-clinical Randomized Cross-over Trial · NA · unknown

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04106453 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Universitätsklinikum Köln
Last refreshed: 5 February 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04106453.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing