NCT04104789 is a Phase 2 clinical trial of Kovanaze Nasal Spray in Caries,Dental, sponsored by Virginia Commonwealth University.

Who is sponsoring NCT04104789?

NCT04104789 is sponsored by Virginia Commonwealth University.

What drugs are being tested in NCT04104789?

Interventions in NCT04104789: Kovanaze Nasal Spray, Articaine Injection.

What condition does NCT04104789 study?

NCT04104789 studies Caries,Dental, Apical Periodontitis.

Is NCT04104789 still recruiting?

NCT04104789 is currently withdrawn. Last updated 11 October 2024.

Last reviewed 2024-10-11 · How we verify

NCT04104789

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth: A Randomized Clinical Trial

Withdrawn Phase 2 Last updated 11 October 2024

What this trial tests

Phase 2 trial testing Kovanaze Nasal Spray in Caries,Dental. Withdrawn.

Timeline

1 September 2020

Primary endpoint
1 September 2021

1 October 2021

Quick facts

Lead sponsor	Virginia Commonwealth University
Phase	Phase 2
Status	Withdrawn
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Start date	1 September 2020
Primary completion	1 September 2021
Estimated completion	1 October 2021

Drugs / interventions tested

Kovanaze Nasal Spray — full drug profile →
Articaine Injection — full drug profile →

Conditions studied

Caries,Dental — all drugs for Caries,Dental →
Apical Periodontitis — all drugs for Apical Periodontitis →

Sponsor

Virginia Commonwealth University

Who can join

18 and older, any sex, with Caries,Dental or Apical Periodontitis. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Success rate of pupal anesthesia
Time frame: immediately after dental procedure, an average of 3 hours
% dental procedures completed without the need for rescue anesthesia

Sponsor's own description

The primary goal of the study is to compare the success rates of pulpal anesthesia (defined as ability to complete the intended dental procedure without the need for rescue anesthesia) between Kovanaze nasal mist and Articaine needle anesthesia.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other trials of Kovanaze Nasal Spray

Trials testing the same drug.

NCT03962634 — Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth - Pediatric · Phase 2 · terminated

Other recruiting trials for Caries,Dental

Currently open trials in the same condition.

NCT07323433 — Efficacy of a Chitosan Dressing in Pulpotomy of Immature Permanent Teeth · NA · recruiting
NCT06690229 — Evaluation of Different Cementation Materials Used in Prefabricated Pediatric Zirconia Crowns · NA · active not recruiting
NCT06453005 — Comparative Evaluation of SMART Hall Technique Vs. Conventional SS Crown in Primary Molars: a Randomized Clinical Trial · NA · recruiting
NCT05860712 — Evaluation of Antimicrobial, Post Operative Pain of Cinnamon Extract Versus Sodium Hypochlorite Irrigant Following Pulpe · NA · recruiting
NCT05969756 — Early Treatments for Preventing Occlusal Caries Lesions · NA · active not recruiting

Other Virginia Commonwealth University trials

Trials by the same sponsor.

NCT05936931 — Young Adult-Mediated Intervention to Increase Colorectal Cancer Screening · NA · not yet recruiting
NCT07365839 — Cemiplimab +/- Fianlimab Post Y90 Radioembolization in Patients With Hepatocellular Carcinoma · Phase 1 · not yet recruiting
NCT07178158 — Enhancing Addiction Treatment Through Psychoeducation · NA · not yet recruiting
NCT07531316 — Safety and Tolerability Study of VVZ-2471 in Healthy Volunteers · Phase 1 · not yet recruiting
NCT07426913 — Cardiovascular Health Education Via Virtual Reality for Breast Cancer Survivors Receiving Anthracyclines or Trastuzumab · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04104789 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Virginia Commonwealth University
Last refreshed: 11 October 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04104789.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing