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NCT04103411: DIISCCO
Effect of High-Intensity Interval Training Compared to Hydrochlorothiazide on Ambulatory Blood Pressure
NA trial testing 24h-Ambulatory Blood Pressure in Hypertension,Essential in 60 participants. Status unknown.
1 June 2021
Quick facts
| Lead sponsor | Anil Nigam |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | prevention |
| Enrollment | 60 |
| Start date | 26 April 2018 |
| Primary completion | 1 June 2021 |
| Estimated completion | 10 January 2022 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- 24h-Ambulatory Blood Pressure
Conditions studied
- Hypertension,Essential — all drugs for Hypertension,Essential →
- Exercise Activity — all drugs for Exercise Activity →
Sponsor
Anil Nigam
Who can join
60 and older, any sex, with Hypertension,Essential or Exercise Activity. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The number of persons with hypertension is increasing and with it the number of related cardiovascular events and related functional or cognitive declines. While studies have suggested that physical activity, in particular, high-intensity interval training (HIIT), could be as efficient as the commonly used antihypertensive medications, no studies have actually compared their effects in the same population. This protocol will determine if HIIT is at least as efficient as hydrochlorothiazide in order to lower 24h-ambulatory blood pressure (BP) in prehypertensive older adults.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
High-intensity interval training vs. hydrochlorothiazide on blood pressure, cardiovascular health and cognition: Protocol of a non-inferiority trial.
Langeard A, Cloutier SO, Olmand M, Saillant K, et al · · 2021 · cited 1× · PMID 33484896 · DOI 10.1016/j.cct.2021.106286
Verify or expand the search:
- PubMed search for NCT04103411
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04103411 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Anil Nigam
- Last refreshed: 25 September 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04103411.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing