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Reducing Particulate Matter-associated Cardiovascular Health Effects for Seniors
NA trial testing air filtration with air purifier with hepa filter in Cardiometabolic Health in 52 participants. Completed in 1 November 2024.
| Lead sponsor | University of Michigan |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | triple |
| Primary purpose | prevention |
| Enrollment | 52 |
| Start date | 24 February 2020 |
| Primary completion | 1 November 2024 |
| Estimated completion | 1 November 2024 |
| Sites | 1 location across United States |
University of Michigan
60 and older, any sex, with Cardiometabolic Health. Patients with the condition only — healthy volunteers not accepted.
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Systolic blood pressure was measured twice a day, in the morning and the evening, from Tuesday through Friday during the first and fourth week of each of the four-week periods in which participants were exposed to one of the interventions. Results reflect the average of systolic readings taken.
| Group | Value | 95% CI |
|---|---|---|
| Air Filtration With Hepa Filter | 127.0 | ± 16.2 |
| Air Filtration With Hepa Filter Removed | 126.5 | ± 16.0 |
Diastolic blood pressure was measured twice a day, in the morning and the evening, from Tuesday through Friday during the first and fourth week of each of the four-week periods in which participants were exposed to one of the interventions. Results reflect the average of diastolic readings taken.
| Group | Value | 95% CI |
|---|---|---|
| Air Filtration With Hepa Filter | 75.1 | ± 10.6 |
| Air Filtration With Hepa Filter Removed | 75.3 | ± 10.4 |
Atmospheric particulate matter was measured daily in the units of ug/m3 and determined using a portable analyzer (PDR-1500). Results reflect the average amount of atmospheric particulate matter present per day.
| Group | Value | 95% CI |
|---|---|---|
| Air Filtration With Hepa Filter | 1.3 | ± 1.5 |
| Air Filtration With Hepa Filter Removed | 8.3 | ± 12.8 |
Atmospheric particulate matter was measured daily in units of ug/m3 and determined using a portable analyzer (PDR-1500). Results reflect the average amount of atmospheric particulate matter present per day.
| Group | Value | 95% CI |
|---|---|---|
| Air Filtration With Hepa Filter | 10.3 | ± 5.8 |
| Air Filtration With Hepa Filter Removed | 8.9 | ± 2.3 |
PM2.5 mass measured from the filters contained in the personal particulate monitors worn for 24-hours by participants performed on the last week of each cross-over limb (twice per participant in total). 24-hour data collection for personal PM2.5 exposure was collected from Thursday morning at 9 am to Friday morning at 9 am during trial week 4 and during trial week 10.
| Group | Value | 95% CI |
|---|---|---|
| Air Filtration With Hepa Filter | 5.1 | ± 4.6 |
| Air Filtration With Hepa Filter Removed | 12.4 | ± 15.6 |
Exposure to fine particulate matter (PM2.5) air pollution is an established risk factor for cardiovascular (CV) morbidity.
1 peer-reviewed publication reference this trial (live from Europe PMC):
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