Last reviewed · How we verify
NCT04100213
Real-Time Assessment of Stress and Stress Response
NA trial testing Trier Social Stress Test in Psychiatric Disorder. Withdrawn.
1 December 2025
Quick facts
| Lead sponsor | Psychiatric University Hospital, Zurich |
|---|---|
| Phase | NA |
| Status | Withdrawn |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | screening |
| Start date | 1 December 2025 |
| Primary completion | 1 December 2025 |
| Estimated completion | 1 December 2025 |
| Sites | 1 location across Switzerland |
Drugs / interventions tested
- Trier Social Stress Test
Conditions studied
- Psychiatric Disorder — all drugs for Psychiatric Disorder →
- Stress Reaction — all drugs for Stress Reaction →
- Stress, Psychological — all drugs for Stress, Psychological →
- Stress, Physiological — all drugs for Stress, Physiological →
Sponsor
Psychiatric University Hospital, Zurich
Who can join
Adults 18 to 65, any sex, with Psychiatric Disorder or Stress Reaction. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Stress is a complex natural phenomenon, frequently related to a physiological response, including heart rate, heart rate variability, respiratory rate, skin conductance and temperature. The subjective experience varies greatly; broadly, it may be conceived as a freeze, flight, fight, fright or faint response. Many studies have demonstrated the negative influence of psychological stress on health and well-being. Through the digital phenotyping of physiological and psychological stress reactions, in a controlled laboratory setting (Trier Social Stress Test- TSST) and real-life situations, in a population of healthy participants and patients with a major psychiatric disorder, we expect to find reliable and valid digital biomarkers. The results of this study will, therefore, not only contribute to a better understanding of stress and stress response but also have the potential to improve diagnostic and treatment approaches.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Real-Time Assessment of Stress and Stress Response Using Digital Phenotyping: A Study Protocol.
Egger ST, Knorr M, Bobes J, Bernstein A, et al · · 2020 · cited 2× · PMID 34713030 · DOI 10.3389/fdgth.2020.544418
Verify or expand the search:
- PubMed search for NCT04100213
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Trier Social Stress Test
Trials testing the same drug.
- NCT06977178 — Adverse Adolescent Pathways to Substance Use · NA · recruiting
- NCT06105853 — Neurobehavioral Profiles of Adaptive Stress Responses in Individuals With Alcohol Use Disorder · NA · recruiting
- NCT05795634 — Cognitive Vulnerability to Stress in Individuals at Risk for Alzheimer's Disease · NA · recruiting
- NCT05570721 — Depression, Aging, Stress and Heart Health Study · NA · recruiting
- NCT05992272 — Cue Effects in Human Addiction: Pavlovian to Instrumental Transfer · recruiting
Other recruiting trials for Psychiatric Disorder
Currently open trials in the same condition.
- NCT07282158 — Adapted Helping Ovarian Cancer Patients Cope Intervention to Address Burnout for Gynecologic Oncology Clinicians · NA · recruiting
- NCT06977503 — Electrotherapy Stimulation Together With Life Coaching for the Support of Burnout Symptoms in Healthcare Workers · NA · recruiting
- NCT07354633 — Full Sail Ahead, Sailing in Psychosocial Rehabilitation. · NA · recruiting
- NCT07053098 — External Facilitation to Increase Prescribing of AUD Medications in the Psychiatric Setting · NA · recruiting
- NCT06376734 — Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness · Phase 2 · recruiting
Other Psychiatric University Hospital, Zurich trials
Trials by the same sponsor.
- NCT05939765 — Pharmacologic Treatment in Legal Offenders With Schizophrenia, a Prospective Observational Mirror Image Study. · withdrawn
- NCT04096625 — Enhancement of a Psychotherapeutic Intervention Through Transcranial Direct Current Stimulation (tDCS) · NA · unknown
- NCT05902819 — Reconsolidation Blockade of Intrusive Trauma- and Cocaine-related Memories · NA · completed
- NCT05911529 — Motivational Interviewing for Patients With Acute Psychosis · NA · completed
- NCT05418075 — Evaluation of the Effectiveness of Add-on Hometreatment to Family Based Therapy in Adolescent Anorexia Nervosa. · NA · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04100213 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Psychiatric University Hospital, Zurich
- Last refreshed: 8 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04100213.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing