NCT04100148 (SyncAV) is a NA clinical trial of SyncAV programmed ON in Congestive Heart Failure, sponsored by Abbott Medical Devices.

Who is sponsoring NCT04100148?

NCT04100148 is sponsored by Abbott Medical Devices.

What drugs are being tested in NCT04100148?

Interventions in NCT04100148: SyncAV programmed ON, Fixed AV delay.

What condition does NCT04100148 study?

NCT04100148 studies Congestive Heart Failure.

Is NCT04100148 still recruiting?

NCT04100148 is currently active, enrolled. Last updated 18 December 2025.

Last reviewed 2025-12-18 · How we verify

NCT04100148: SyncAV

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

SyncAV Post-Market Trial

Active, enrolled NA Last updated 18 December 2025

What this trial tests

NA trial testing SyncAV programmed ON in Congestive Heart Failure in 1,686 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

3 October 2019

Primary endpoint
31 May 2026

30 June 2026

Quick facts

Lead sponsor	Abbott Medical Devices
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	1,686
Start date	3 October 2019
Primary completion	31 May 2026
Estimated completion	30 June 2026
Sites	104 locations across Hong Kong, Italy, Finland, Japan, Taiwan, Poland, South Korea, Netherlands

Drugs / interventions tested

SyncAV programmed ON
Fixed AV delay

Conditions studied

Congestive Heart Failure — all drugs for Congestive Heart Failure →

Sponsor

Abbott Medical Devices — full company profile →

Who can join

18 and older, any sex, with Congestive Heart Failure. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The SyncAV Post-Market Trial is a prospective, randomized, multi-center trial performed to determine if cardiac resynchronization therapy (CRT) devices programmed with SyncAV ON improve long-term CRT response compared to devices programmed with conventional CRT through evaluation of changes in left ventricular (LV) reverse remodeling.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Balancing right ventricular paced and right bundle branch activation to electrically optimize cardiac resynchronization therapy: triple-fusion pacing.
Wisnoskey B, Varma N. · · 2024 · cited 3× · PMID 38651191 · DOI 10.1093/europace/euae084
Fine-tuning delivery of cardiac resynchronization therapy: Optimization for "triple fusion".
Varma N. · · 2021 · cited 2× · PMID 34194995 · DOI 10.1016/j.hrcr.2021.03.019
Therapy for cardiac resynchronization: When left ventricular-only "fusion" pacing is not enough.
Varma N. · · 2020 · cited 2× · PMID 33365250 · DOI 10.1016/j.hrcr.2020.08.020
Acute Electrical Synchronization Achieved With Dynamic Atrioventricular Delays During Biventricular and Left Ventricular MultiPoint Pacing.
Thibault B, Waddingham P, Badie N, Mangual JO, et al · · 2025 · cited 1× · PMID 40060211 · DOI 10.1016/j.cjco.2024.11.003

Verify or expand the search:

Other recruiting trials for Congestive Heart Failure

Currently open trials in the same condition.

NCT07008365 — The Role of intraABDOminal Pressure and Point Of Care UltraSound to Guide Decongestive Therapy in Heart Failure · Phase 3 · recruiting
NCT06526884 — Quasi-Randomized Evaluation of the UCLA Next Day Clinic (NDC) · NA · active not recruiting
NCT06495892 — PVP-Guided Decongestive Therapy in HF 2 · Phase 4 · recruiting
NCT06374277 — Pharmacy-led Transitions of Care Intervention to Improve Medication Adherence · NA · recruiting
NCT05971225 — Verifying Remote Monitoring Effect on Net Cardiovascular Outcome; RemoteVerify (RêVe) · NA · recruiting

Other Abbott Medical Devices trials

Trials by the same sponsor.

NCT07421076 — Grid eXplore Mapping Study · NA · recruiting
NCT07509658 — TriClip Japan Post-Approval Study · recruiting
NCT07361445 — Agilis RF TSP Early Feasibility Study · NA · recruiting
NCT07373353 — A Clinical Evaluation of AMJ-401 · NA · recruiting
NCT07217392 — Left Bundle Branch Area Pacing (LBBAP) PMCF Study · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04100148 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Abbott Medical Devices
Last refreshed: 18 December 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04100148.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing