NCT04096651: Gait-PSP

Pathophysiology of Gait and Posture in Progressive Supranuclear Palsy

Completed NA Last updated 20 September 2019

What this trial tests

NA trial testing gait recordings in Progressive Supranuclear Palsy in 48 participants. Completed in 12 July 2018.

Timeline

28 September 2015

Primary endpoint
12 July 2018

12 July 2018

Quick facts

Lead sponsor	Centre Hospitalier Universitaire de la Guadeloupe
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	basic science
Enrollment	48
Start date	28 September 2015
Primary completion	12 July 2018
Estimated completion	12 July 2018

Drugs / interventions tested

• gait recordings
• brain magnetic resonance imaging
• oculomotor movement recordings

Conditions studied

• Progressive Supranuclear Palsy — all drugs for Progressive Supranuclear Palsy →

Sponsor

Centre Hospitalier Universitaire de la Guadeloupe

Who can join

40 and older, any sex, with Progressive Supranuclear Palsy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The main hypothesis is that the gait and postural deficits in the Caribbean form of PSP may be associated with a dysfunction of the cerebral cortex, as they result from sub-cortical involvement in classical forms. The investigators will characterize the gait and posture with a force platform to collect biomechanical gait parameters, coupled with the kinematic and electromyographic (EMG) study. Then the investigators realize a multimodal imaging study \[structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI)\] that allow us to determine if a correlation can be found between the clinical characteristics of postural control and walking on one hand, and morphological changes and structural MRI changes in cortico-subcortical pathways on the other hand. The study of performance on neuropsychological tests, registration of ocular movements and the analysis of functional cortical activity will complete our multimodal approach. A better understanding of these disorders is expected to propose new drug treatment and rehabilitative strategies.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Brain dysfunction in gait disorders of Caribbean atypical Parkinsonism and progressive supranuclear palsy patients: A comparative study.
   Welter ML, Vasseur A, Edragas R, Chaumont H, et al · · 2023 · cited 4× · PMID 37247501 · DOI 10.1016/j.nicl.2023.103443