NCT04096248: CLEAR

CT (Computerized Tomography) for Late EndovasculAr Reperfusion

Completed Last updated 4 June 2024

What this trial tests

trial in Stroke, Cardiovascular in 2,790 participants. Completed in 1 May 2022.

Timeline

15 February 2020

Primary endpoint
23 May 2021

1 May 2022

Quick facts

Lead sponsor	Boston Medical Center
Status	Completed
Study type	OBSERVATIONAL
Enrollment	2,790
Start date	15 February 2020
Primary completion	23 May 2021
Estimated completion	1 May 2022
Sites	19 locations across France, Finland, Japan, Belgium, Germany, Canada, Switzerland, Portugal

Conditions studied

• Stroke, Cardiovascular — all drugs for Stroke, Cardiovascular →

Sponsor

Boston Medical Center

Who can join

18 and older, any sex, with Stroke, Cardiovascular. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The objective of this multicenter, retrospective, cross-sectional, chart review study is to compare outcomes (disability, complications and mortality) of patients with large vessel occlusion stroke presenting at late time window selected by either Non-Contrast CT (NCCT) only, advanced imaging with CTP (Computed Tomography Perfusion), MRI (Magnetic Resonance Imaging), or medical management.

Boston Medical Center (BMC) will serve as the main data coordinating site. Fifteen additional sites will seek local IRB approval or ethics approval. The aggregated de-identified data will be analyzed comparing types of interventions and outcomes by type of imaging or medical management.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Noncontrast Computed Tomography vs Computed Tomography Perfusion or Magnetic Resonance Imaging Selection in Late Presentation of Stroke With Large-Vessel Occlusion.
   Nguyen TN, Abdalkader M, Nagel S, Qureshi MM, et al · · 2022 · cited 209× · PMID 34747975 · DOI 10.1001/jamaneurol.2021.4082
2. Reperfusion Without Functional Independence in Late Presentation of Stroke With Large Vessel Occlusion.
   Seker F, Qureshi MM, Möhlenbruch MA, Nogueira RG, et al · · 2022 · cited 86× · PMID 36252092 · DOI 10.1161/strokeaha.122.039476
3. Endovascular vs Medical Management for Late Anterior Large Vessel Occlusion With Prestroke Disability: Analysis of CLEAR and RESCUE-Japan.
   Siegler JE, Qureshi MM, Nogueira RG, Tanaka K, et al · · 2023 · cited 27× · PMID 36332983 · DOI 10.1212/wnl.0000000000201543
4. Noncontrast CT Selected Thrombectomy vs Medical Management for Late-Window Anterior Large Vessel Occlusion.
   Nguyen TN, Nogueira RG, Qureshi MM, Nagel S, et al · · 2024 · cited 23× · PMID 38709999 · DOI 10.1212/wnl.0000000000209324
5. Safety and clinical outcomes of endovascular therapy versus medical management in late presentation of large ischemic stroke.
   Mujanovic A, Strbian D, Demeestere J, Marto JP, et al · · 2024 · cited 13× · PMID 38757713 · DOI 10.1177/23969873241249406
6. CLEAR Thrombectomy Score: An Index to Estimate the Probability of Good Functional Outcome With or Without Endovascular Treatment in the Late Window for Anterior Circulation Occlusion.
   Siegler JE, Koneru M, Qureshi MM, Doheim M, et al · · 2024 · cited 11× · PMID 38979812 · DOI 10.1161/jaha.124.034948
7. Outcomes of Bridging Intravenous Thrombolysis Versus Endovascular Therapy Alone in Late-Window Acute Ischemic Stroke.
   Demeestere J, Qureshi MM, Vandewalle L, Wouters A, et al · · 2024 · cited 10× · PMID 38748598 · DOI 10.1161/strokeaha.124.046495
8. Endovascular Therapy for Patients With Low NIHSS Scores and Large Vessel Occlusion in the 6- to 24-Hour Window: Analysis of the CLEAR Study.
   Marto JP, Qureshi M, Nagel S, Nogueira RG, et al · · 2025 · cited 5× · PMID 40112237 · DOI 10.1212/wnl.0000000000213442