NCT04092439: WMJ

The Effects of Watermelon Juice Supplementation on Postprandial Vascular Endothelial Function

Completed NA Results posted Last updated 30 July 2024

What this trial tests

NA trial testing Watermelon Juice in Endothelial Dysfunction in 18 participants. Completed in 20 March 2020.

Timeline

12 September 2019

Primary endpoint
20 March 2020

20 March 2020

Quick facts

Lead sponsor	Pennington Biomedical Research Center
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	treatment
Enrollment	18
Start date	12 September 2019
Primary completion	20 March 2020
Estimated completion	20 March 2020
Sites	1 location across United States

Drugs / interventions tested

• Watermelon Juice

Conditions studied

• Endothelial Dysfunction — all drugs for Endothelial Dysfunction →

Sponsor

Pennington Biomedical Research Center — full company profile →

Who can join

Adults 18 to 40, any sex, with Endothelial Dysfunction. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Endothelial Function Primary · Two weeks

Flow mediated dilation

Group	Value	95% CI
Placebo	3.31	± 0.65
Watermelon Juice	3.53	± .65

Postprandial Blood Flow Secondary · Two weeks

microvascular blood flow

Group	Value	95% CI
Placebo	36.0	± 20.5
Watermelon Juice	51.0	± 29.1

Sponsor's own description

The purpose of this study is to test if watermelon juice supplementation improves vascular dysfunction experience during hyperglycemia.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Supplemental Watermelon Juice Attenuates Acute Hyperglycemia-Induced Macro-and Microvascular Dysfunction in Healthy Adults.
   Vincellette CM, Losso J, Early K, Spielmann G, et al · · 2021 · cited 13× · PMID 34510203 · DOI 10.1093/jn/nxab279
2. The Effect of Watermelon Juice Supplementation on Heart Rate Variability and Metabolic Response during an Oral Glucose Challenge: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial.
   Matthews R, Early KS, Vincellette CM, Losso J, et al · · 2023 · PMID 36839167 · DOI 10.3390/nu15040810