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NCT04089501
The Role of the Pregnane X Receptor (PXR) in Indole Signaling and Intestinal Permeability in Inflammatory Bowel Disease
trial testing Stool collection in Inflammatory Bowel Diseases in 43 participants. Completed in 2 May 2019.
2 May 2019
Quick facts
| Lead sponsor | Albert Einstein College of Medicine |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 43 |
| Start date | 25 February 2015 |
| Primary completion | 2 May 2019 |
| Estimated completion | 2 May 2019 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Stool collection — full drug profile →
- Biopsy collection
Conditions studied
- Inflammatory Bowel Diseases — all drugs for Inflammatory Bowel Diseases →
Sponsor
Albert Einstein College of Medicine
Who can join
Under 65, any sex, with Inflammatory Bowel Diseases. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this study is to better understand the mechanisms responsible for the development of and the severity of Inflammatory Bowel Disease (IBD), such as Crohn's Disease and Ulcerative Colitis, which cause inflammation of the gut as well as potentially affecting other areas of the body
Publications & conference data
4 peer-reviewed publications reference this trial (live from Europe PMC):
-
Bile Salt Hydrolase-Competent Probiotics in the Management of IBD: Unlocking the "Bile Acid Code".
Gadaleta RM, Cariello M, Crudele L, Moschetta A. · · 2022 · cited 39× · PMID 35956388 · DOI 10.3390/nu14153212 -
Mixture Effects of Tryptophan Intestinal Microbial Metabolites on Aryl Hydrocarbon Receptor Activity.
Vrzalová A, Pečinková P, Illés P, Gurská S, et al · · 2022 · cited 21× · PMID 36142735 · DOI 10.3390/ijms231810825 -
Deciphering structural bases of intestinal and hepatic selectivity in targeting pregnane X receptor with indole-based microbial mimics.
Li H, Illés P, Karunaratne CV, Nordstrøm LU, et al · · 2021 · cited 13× · PMID 33636438 · DOI 10.1016/j.bioorg.2021.104661 -
A Century of Bacteriophages: Insights, Applications, and Current Utilization.
Dkhili S, Ribeiro M, Slama KB. · · 2025 · PMID 41301576 · DOI 10.3390/antibiotics14111080
Verify or expand the search:
- PubMed search for NCT04089501
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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- NCT04301973 — Stools and Life Habits Collection in Heathy Volunteers/Subjects - to Provide Material for in Vitro Model Development · NA · completed
Other recruiting trials for Inflammatory Bowel Diseases
Currently open trials in the same condition.
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- NCT07349472 — Pentoxifylline in Patients With Ulcerative Colitis · Phase 2 · recruiting
- NCT07033208 — Feasibility of a Wireless Thermal Capsule Endoscopy to Detect Gastrointestinal Thermal Variance · NA · recruiting
- NCT06842316 — Effects of Phytocannabinoids on Immune Response and Autophagy During Chronic Immune-mediated Inflammatory Diseases · recruiting
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Other Albert Einstein College of Medicine trials
Trials by the same sponsor.
- NCT07526948 — Vaginal Estradiol vs Moisturizer to Improve Postmenopausal Vaginal Aging Symptoms and the Microbiome in Women Living Wit · Phase 4 · not yet recruiting
- NCT07225400 — Designing a Spatial Navigation Intervention Protocol Informed by Region-specific Brain Activation for Mild Cognitive Imp · NA · not yet recruiting
- NCT07464236 — Improving Clinic Delivery of HIV-related Anal Health Services · NA · not yet recruiting
- NCT06543355 — The Acupuncture for Pain, Opioid Use Disorder and Mood · NA · completed
- NCT05588193 — ED2PrEP - Patient Focused, Low-burden Strategies for PrEP Uptake Among Emergency Departments · NA · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04089501 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Albert Einstein College of Medicine
- Last refreshed: 16 September 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04089501.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing