Proportion of Clinical Improvement and Score Comparison of Type 1 Interferon, Transcriptomic Analysis in Idiopathic Uveitis Patients With IGRA Positive Before and After Anti-Tuberculosis Drugs Treatment: Cohort Prospective Study

NCT04088019 UNKNOWN

The aim of this study is to determine the proportion of clinical improvement, the score changing of type 1 interferon selected gene expression, and analysis of transcriptomics profiling in patients with idiopathic uveitis positive IGRA before and after receiving Anti-Tuberculosis Therapy (ATT). Hopefully, by conducting this research, we are able to provide valid data that demonstrate the advantages/disadvantages usage of Anti-Tuberculosis Therapy in patients with idiopathic uveitis IGRA positive that correlate with type I IFN. This research is a part of our efforts in discovering bio-marker candidates of idiopathic uveitis IGRA positive clinical patients who will benefit from the ATT administration.

Details

Lead sponsor	Fakultas Kedokteran Universitas Indonesia
Status	UNKNOWN
Enrolment	50
Start date	2019-10-30
Completion	2024-07

Conditions

• Tuberculosis; Uveitis (Manifestation)
• Anti-Tuberculous Drug Reaction
• Tuberculous Uveitis

Interventions

• Fixed drug combination (FDC) of ATT and Oral steroid

Primary outcomes

• Proportion of clinical improvement — 0, 14 days, 8 weeks, 3 months, 6 months, and 12 months
  Clinical improvement of uveitis patients with IGRA positive after receiving complete Anti Tuberculosis Therapy is measured by using The Standardization of Uveitis Nomenclature (SUN) inflammation degree. Clinical improvement definition is decreasing of inflammation degree up to two degrees or becoming 0 degree. Meanwhile, clinical failure is defined by increasing of inflammation degree or decreasing of inflammation degree up to one degree/ not becoming 0 degree or unchanged degree of first to fourth degree.
• The changes of type 1 interferon scoring in selected gene expression — 0, 14 days, 6 months.
  The score changes of type 1 interferon of uveitis patients with IGRA positive are determined by gene expression value of 10 varieties of type 1 interferon using Quantitative Reverse Transcriptase PCR (RT-qPCR) testing.

Countries

Indonesia