Last reviewed · How we verify
NCT04081519
Stimulation of Parieto-hippocampal Connectivity in Patients With Major Depressive Disorder
NA trial testing active rTMS over DLPFC in Depression in 53 participants. Completed in 22 June 2018.
31 March 2018
Quick facts
| Lead sponsor | University Hospital, Bonn |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 53 |
| Start date | 2 August 2016 |
| Primary completion | 31 March 2018 |
| Estimated completion | 22 June 2018 |
| Sites | 1 location across Germany |
Drugs / interventions tested
- active rTMS over DLPFC
- Add-on active rTMS over DLPFC
- Add-on active rTMS over LPC
- Add-on sham rTMS
Conditions studied
- Depression — all drugs for Depression →
- Depressive Disorder — all drugs for Depressive Disorder →
- Depressive Episode — all drugs for Depressive Episode →
- Depressive Disorder, Major — all drugs for Depressive Disorder, Major →
Sponsor
University Hospital, Bonn
Who can join
Adults 18 to 60, any sex, with Depression or Depressive Disorder. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study aims to investigate the effects of individualized repetitive transcranial magnetic stimulation (rTMS) of parieto-hippocampal functional connectivity in patients with major depressive disorder (MDD). Specifically, patients will be randomized to one of three groups and will receive 15 days of rTMS over three weeks. Each day they will receive one active session of rTMS over the dorsolateral parietal cortex (DLPFC) and depending on group assignment another session either A) active rTMS over DLPFC, B) active rTMS over left and right lateral parietal cortex (LPC), or C) sham rTMS over DLPFC or LPC. Stimulation targets in the LPC will be individualized for each patient based on their resting-state functional connectivity between the hippocampus and LPC. Clinical, neuropsychological and fMRI data will be acquired before and after the treatment course.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04081519
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other University Hospital, Bonn trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04081519 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Bonn
- Last refreshed: 4 August 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04081519.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing