Effect of Glucose-6-phosphate Dehydrogenase Deficiency on Donor Red Blood Cell Storage

NCT04081272 COMPLETED

The proposed study will determine whether G6PD-deficient RBCs store differently than normal RBCs under standard blood banking conditions. The investigators plan to screen a large number of healthy male volunteers for G6PD deficiency in order to identify 10 G6PD deficient and 30 matched normal individuals using a blood sample obtained from a finger-stick. The identified individuals will then be asked to donate a unit of blood that will be stored for up to 42 days and various tests will be performed on these units during storage. At 6 weeks of storage a portion of the unit will be radioactively labeled and re-infused into the volunteer. Blood samples will be drawn before, during, and after the infusion to measure how well or poorly the red blood cells survive after transfusion.

Details

Lead sponsor	Columbia University
Status	COMPLETED
Enrolment	40
Start date	2012-11
Completion	2017-10

Conditions

• G6PD Deficiency

Interventions

• Sodium Chromate Cr51

Primary outcomes

• 24-hour post-transfusion red blood cell recovery — 24 hours
  Percentage of radio-labeled red blood cells remaining 24 hours after infusion

Countries

United States