Who is sponsoring NCT04078516?

NCT04078516 is sponsored by Aalborg University Hospital.

What drugs are being tested in NCT04078516?

Interventions in NCT04078516: Perception Threshold Tracking (PTT), Axon-flair mediated respons, Heart rate variability, Quantitative Sensory Testing (QST), Peripheral blood pressure and transcutaneous oxygen tension, Magnetic Resonance Imaging (MRI), Questionnaires, Corneal Confocal Microscopy /CCM).

What condition does NCT04078516 study?

NCT04078516 studies Neuropathy, Diabetic, Neuropathy, Painful.

Is NCT04078516 still recruiting?

NCT04078516 is currently completed. Last updated 2 November 2021.

Last reviewed 2021-11-02 · How we verify

NCT04078516: MEDON

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Methods of Early Detection and Grading Of Diabetic Peripheral Neuropathy (MEDON)

Completed Last updated 2 November 2021

What this trial tests

trial testing Perception Threshold Tracking (PTT) in Neuropathy, Diabetic in 80 participants. Completed in 31 August 2021.

Timeline

12 August 2019

Primary endpoint
31 August 2021

31 August 2021

Quick facts

Lead sponsor	Aalborg University Hospital
Status	Completed
Study type	OBSERVATIONAL
Enrollment	80
Start date	12 August 2019
Primary completion	31 August 2021
Estimated completion	31 August 2021
Sites	1 location across Denmark

Drugs / interventions tested

Perception Threshold Tracking (PTT)
Axon-flair mediated respons
Heart rate variability
Quantitative Sensory Testing (QST)
Peripheral blood pressure and transcutaneous oxygen tension
Magnetic Resonance Imaging (MRI)
Questionnaires
Corneal Confocal Microscopy /CCM)

Conditions studied

Neuropathy, Diabetic — all drugs for Neuropathy, Diabetic →
Neuropathy, Painful — all drugs for Neuropathy, Painful →

Sponsor

Aalborg University Hospital

Who can join

Adults 18 to 70, any sex, with Neuropathy, Diabetic or Neuropathy, Painful. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

MEDON aims to examine new methods for early detection and grading of diabetic peripheral neuropathy focusing on both small- and large nerve fibers. Furthermore, MEDON aims to describe differences between people with classic diabetic peripheral neuropathy and those with painful diabetic neuropathy.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

Cognitive function in individuals with and without painful and painless diabetic polyneuropathy-A cross-sectional study in type 1 diabetes.
Croosu SS, Gjela M, Røikjer J, Hansen TM, et al · · 2023 · cited 12× · PMID 37073434 · DOI 10.1002/edm2.420
57<sup>th</sup> EASD Annual Meeting of the European Association for the Study of Diabetes.
· 2021 · cited 11× · PMID 34468792 · DOI 10.1007/s00125-021-05519-y
Diagnostic Accuracy of Perception Threshold Tracking in the Detection of Small Fiber Damage in Type 1 Diabetes.
Røikjer J, Croosu SS, Sejergaard BF, Hansen TM, et al · · 2024 · cited 10× · PMID 36825610 · DOI 10.1177/19322968231157431
58<sup>th</sup> EASD Annual Meeting of the European Association for the Study of Diabetes : Stockholm, Sweden, 19 - 23 September 2022.
· 2022 · cited 6× · PMID 35920845 · DOI 10.1007/s00125-022-05755-w
Corneal Immune Cells and Their Relation to Diabetic Peripheral Neuropathy and Neuropathic Pain.
Moussa F, Taleb S, Borbjerg MK, Croosu SS, et al · · 2026 · cited 1× · PMID 41246983 · DOI 10.1002/mus.70061

Verify or expand the search:

Other recruiting trials for Neuropathy, Diabetic

Currently open trials in the same condition.

NCT06471517 — Neuroprosthetic Device for Improving Issues Caused by Diabetic Neuropathy With Specifically Designed Neural Stimulation · NA · recruiting
NCT06376240 — The Effect of Pyridoxamine Supplementation on Microvascular Function in Type 2 Diabetes · NA · active not recruiting
NCT05546138 — Characterization and Prediction of Early Onset Diabetic Peripheral Neuropathy · recruiting

Other Aalborg University Hospital trials

Trials by the same sponsor.

NCT06960005 — ThyMoves: Screening and Exercise to Improve Muscle, Enhance Quality of Life, and Reduce Fall Risk in Thyroid Disease · NA · enrolling by invitation
NCT06745544 — Impact of Screening and Multicomponent Exercise on Fall Rates, Fractures, and Cardiovascular Health in Diabetes · NA · recruiting
NCT07185958 — Dual Energy CT - a Tool for Delineation of Tumor and Organs at Risk in Radiotherapy · not yet recruiting
NCT07165574 — Prevalence of Anticholinergics in Geriatric Patients With Acute Functional Deterioration · not yet recruiting
NCT07173413 — Assessing the Quality of Telephone Follow-Up After Spine Surgery · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04078516 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Aalborg University Hospital
Last refreshed: 2 November 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04078516.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing