18 and older, any sex, with Pulmonary Nodule, Solitary or Pulmonary Nodule, Multiple. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Reader Confidence in s-DCT Images Compared to Conventional CT (Units on a Scale)Primary· Baseline
Readers will rate their confidence in images from the experimental modality (sDCT with scatter correction) as compared to the conventional scan (chest CT with x-ray) on a 7 point Likert scale (-3 to 3) based on ability to identify lesion(s) present comparing each modality. A value of -3 is significantly less confident in the s-DCT representation 0 is the same confidence in modalities, and 3 is significantly more confident in the s-DCT representation compared to the conventional. Each individual will have a single value per reader. Two readers compared each scan. The overall reader preference b
Group
Value
95% CI
Scatter Corrected s-DCT
-0.43
± 0.62
Sensitivity of s-DCT Images (Percentage of Positive Scans)Secondary· Baseline
Sensitivity will be defined as the ability of s-DCT images to detect lesions positively identified on gold standard CT images.
Group
Value
95% CI
Scatter Corrected s-DCT
0.407
0.224 – 0.612
Sponsor's own description
This is a study that will evaluate the utility of a scatter reduction technique in reducing dose and increasing the sensitivity of stationary digital chest tomosynthesis (s-DCT) in the detection of lung lesions.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
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Sponsor: as reported to ClinicalTrials.gov by UNC Lineberger Comprehensive Cancer Center
Last refreshed: 8 August 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04076696.