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NCT04057534: Chess_SUD
Neurobiological Mechanisms of Chess as an Add-On Treatment Against SUD
NA trial testing Standard therapy for AUD plus Chess-based cognitive treatment in Substance Use Disorders in 108 participants. Completed in 17 November 2023.
17 November 2023
Quick facts
| Lead sponsor | Central Institute of Mental Health, Mannheim |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 108 |
| Start date | 1 April 2020 |
| Primary completion | 17 November 2023 |
| Estimated completion | 17 November 2023 |
| Sites | 1 location across Germany |
Drugs / interventions tested
- Standard therapy for AUD plus Chess-based cognitive treatment
- Standard therapy for AUD
- Standard smoking cessation therapy for TUD plus Chess-based cognitive treatment
- Standard therapy for TUD
Conditions studied
- Substance Use Disorders — all drugs for Substance Use Disorders →
Sponsor
Central Institute of Mental Health, Mannheim
Who can join
Adults 18 to 65, any sex, with Substance Use Disorders. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Neurobiological and neuropsychological approaches to investigate the potential mechanism of action of chess as an add-on therapy (chess based - cognitive remediation treatment, CB-CRT) to reduce cognitive deficits in individuals with alcohol use disorder (AUD) or tobacco use disorder (TUD).
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effects of chess-based cognitive remediation training as therapy add-on in alcohol and tobacco use disorders: protocol of a randomised, controlled clinical fMRI trial.
Gerhardt S, Lex G, Holzammer J, Karl D, et al · · 2022 · cited 4× · PMID 36691127 · DOI 10.1136/bmjopen-2021-057707
Verify or expand the search:
- PubMed search for NCT04057534
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Central Institute of Mental Health, Mannheim trials
Trials by the same sponsor.
- NCT06845124 — A Trial to Investigate the Effects of Cannabidiol Plus Naltrexone on Alcohol Craving in Patients With Alcohol Dependence · Phase 2 · recruiting
- NCT00916201 — Evaluation Study of New Compounds With Potential Use in Schizophrenia · Phase 1 · withdrawn
- NCT06959342 — Modification of Inhibitory Control and Craving Through Transcranial Direct Current Stimulation (tDCS) as an Add-On Treat · NA · recruiting
- NCT06881810 — Enhancing Social Skills in Schizophrenia Spectrum Disorders - Oxytocin as add-on to Psychosocial Treatment · Phase 2 · recruiting
- NCT05726045 — Increasing Smoking Cessation Success Through Sleep-amplified Memory Consolidation · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04057534 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Central Institute of Mental Health, Mannheim
- Last refreshed: 29 March 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04057534.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing