NCT04052308

Decrease in Blood Pressure in PARQVE

Status unknown NA Last updated 14 August 2019

What this trial tests

NA trial testing ABPM in Knee Osteoarthritis in 63 participants. Status unknown.

Timeline

1 October 2019

Primary endpoint
28 February 2020

31 March 2020

Quick facts

Lead sponsor	University of Sao Paulo General Hospital
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	63
Start date	1 October 2019
Primary completion	28 February 2020
Estimated completion	31 March 2020

Drugs / interventions tested

• ABPM
• The arterial stiffness and endothelial reactivity
• Euroqol EQ-5D-5L
• Lectures about knee OA
• Continuous intensity exercise
• Exercises with varying intensity and interval

Conditions studied

• Knee Osteoarthritis — all drugs for Knee Osteoarthritis →
• Blood Pressure — all drugs for Blood Pressure →

Sponsor

University of Sao Paulo General Hospital

Who can join

60 and older, any sex, with Knee Osteoarthritis or Blood Pressure. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The tripod of OA clinical treatment is education, weight loss and exercise. A sedentary lifestyle has been characterized as an independent risk factor for cardiovascular disease. Studies have shown the inverse association between the level of physical activity and the incidence of cardiovascular disease. High Intensity Interval Training (HIIT), which consists of repeated high-intensity exercise sessions interspersed with passive recovery. Active, has been studied as a new therapeutic approach and has been shown to be effective in controlling blood pressure (BP) and arterial stiffness in treated hypertensive individuals. HIIT training has also been shown to be able to reverse the hemodynamic, metabolic and hormonal changes that are involved in the pathophysiology of essential hypertension, leading to improved arterial stiffness and BP response, endothelin-1 and nitrite / nitrate to exercise, increased cardiorespiratory fitness when compared to moderate-intensity continuous exercise in young women with a family history of essential hypertension. Six weeks of HIIT training (3 times / week) reduced body fat and waist circumference in young women. , while increasing fat-free mass, maximum running speed and aerobic fitness. Two recent studies evaluating body weight change in overweight patients have shown that HIIT training is comparable to moderate-intensity continuous exercise, but HIIT is more efficient compared to time spent training, which may facilitate the inclusion of daily routine training of patients. Previous work performed by the authors patients undergoing an education and physical activity program showed improvement in WOMAC. The investigators believe that the inclusion of an HIIT training protocol may lead to improved BP and hemodynamic variables in patients with knee osteoarthritis. To evaluate the effect of high intensity interval physical training associated with an educational program on BP, hemodynamic variables of individuals undergoing treatment for knee OA. 63 patients with knee OA will be randomized into 3 groups: interval exercise (21), continuous exercise (21) and control (21). Patients will be evaluated for BP using ABPM, arterial stiffness and endothelial reactivity by measuring carotid-femoral pulse wave velocity and quality of life using the Euroqol scale.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.