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NCT04048551
The PrEPARE Project: Prevention, Empowering, and Protecting Young Women in South Africa
NA trial testing Modified Health Policy Project (HPP) HIV-Stigma and Discrimination Reduction Training Curriculum in HIV Prevention in 802 participants. Completed in 23 June 2022.
23 June 2022
Quick facts
| Lead sponsor | RTI International |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | factorial |
| Masking | none |
| Primary purpose | prevention |
| Enrollment | 802 |
| Start date | 4 April 2019 |
| Primary completion | 23 June 2022 |
| Estimated completion | 23 June 2022 |
| Sites | 1 location across South Africa |
Drugs / interventions tested
- Modified Health Policy Project (HPP) HIV-Stigma and Discrimination Reduction Training Curriculum
- Young Women's Health CoOp (YWHC)
Conditions studied
- HIV Prevention — all drugs for HIV Prevention →
Sponsor
RTI International — full company profile →
Who can join
Adults 16 to 24, female only, with HIV Prevention. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The project seeks to determine whether implementing a multilevel, woman-focused intervention, the Young Women's Health CoOp (YWHC), for pre-exposure prophylaxis (PrEP) readiness, uptake, and adherence is a viable complement to the HIV prevention plan for the Government of South Africa. Specifically, this project aims to: increase uptake, of sexual and reproductive health (SRH) services and readiness and uptake of PrEP among adolescent girls and young women (AGYW) aged 16 to 24 who engage in high-risk sexual behaviors; and reduce their barriers to accessing SRH services by addressing and reducing stigma and discrimination (S\&D) in clinics.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
The PrEPARE Pretoria Project: protocol for a cluster-randomized factorial-design trial to prevent HIV with PrEP among adolescent girls and young women in Tshwane, South Africa.
Wechsberg WM, Browne FA, Ndirangu J, Bonner CP, et al · · 2020 · cited 23× · PMID 32933510 · DOI 10.1186/s12889-020-09458-y -
The Importance of the Individual in PrEP Uptake: Multilevel Correlates of PrEP Uptake Among Adolescent Girls and Young Women in Tshwane, South Africa.
Bonner CP, Minnis AM, Ndirangu JW, Browne FA, et al · · 2023 · cited 3× · PMID 37439915 · DOI 10.1007/s10461-023-04126-9
Verify or expand the search:
- PubMed search for NCT04048551
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other RTI International trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04048551 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by RTI International
- Last refreshed: 8 January 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04048551.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing