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NCT04047810
Mesenchymal Stem Cells in the Treatment of Subjects With Advance Chronic Obstructive Pulmonary Disease (COPD)
Completed
Phase 1
Last updated 14 November 2025
What this trial tests
Phase 1 trial testing Mesenchymal Stem Cells in Chronic Obstructive Pulmonary Disease in 15 participants. Completed in 15 August 2025.
Timeline
6 January 2020
Primary endpoint
21 November 2023
21 November 2023
15 August 2025
Quick facts
| Lead sponsor | Mayo Clinic |
|---|---|
| Phase | Phase 1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 15 |
| Start date | 6 January 2020 |
| Primary completion | 21 November 2023 |
| Estimated completion | 15 August 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Mesenchymal Stem Cells — full drug profile →
Conditions studied
- Chronic Obstructive Pulmonary Disease — all drugs for Chronic Obstructive Pulmonary Disease →
Sponsor
Mayo Clinic
Who can join
Adults 18 to 90, any sex, with Chronic Obstructive Pulmonary Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Researchers are trying to understand the effects of mesenchymal stem cells therapy in subjects with advance chronic obstructive pulmonary disease
Publications & conference data
8 peer-reviewed publications reference this trial (live from Europe PMC):
-
Cell therapies in the clinic.
Wang LL, Janes ME, Kumbhojkar N, Kapate N, et al · · 2021 · cited 99× · PMID 34027097 · DOI 10.1002/btm2.10214 -
The Clinical Trials of Mesenchymal Stromal Cells Therapy.
Kouchakian MR, Baghban N, Moniri SF, Baghban M, et al · · 2021 · cited 30× · PMID 34745268 · DOI 10.1155/2021/1634782 -
Lung regeneration: diverse cell types and the therapeutic potential.
Chen Y, Li Z, Ji G, Wang S, et al · · 2024 · cited 24× · PMID 38405059 · DOI 10.1002/mco2.494 -
Clinical applications of mesenchymal stromal cell-based therapies for pulmonary diseases: An Update and Concise Review.
Chen X, Wang F, Huang Z, Wu Y, et al · · 2021 · cited 23× · PMID 34220313 · DOI 10.7150/ijms.59218 -
Stem cell therapy for chronic obstructive pulmonary disease.
Chen YT, Miao K, Zhou L, Xiong WN. · · 2021 · cited 22× · PMID 34250959 · DOI 10.1097/cm9.0000000000001596 -
Current therapeutic strategies for respiratory diseases using mesenchymal stem cells.
Wang MY, Zhou TY, Zhang ZD, Liu HY, et al · · 2021 · cited 21× · PMID 34766151 · DOI 10.1002/mco2.74 -
Stem Cell-Based Regenerative Therapy and Derived Products in COPD: A Systematic Review and Meta-Analysis.
Calzetta L, Aiello M, Frizzelli A, Camardelli F, et al · · 2022 · cited 13× · PMID 35681492 · DOI 10.3390/cells11111797 -
Regenerative and translational medicine in COPD: hype and hope.
Guarnier LP, Moro LG, Lívero FADR, de Faria CA, et al · · 2023 · cited 11× · PMID 37495247 · DOI 10.1183/16000617.0223-2022
Verify or expand the search:
- PubMed search for NCT04047810
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Currently open trials in the same condition.
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Other Mayo Clinic trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
Data sources for this page
- Trial protocol + status: ClinicalTrials.gov NCT04047810 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Mayo Clinic
- Last refreshed: 14 November 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04047810.
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