Last reviewed · How we verify
NCT04044534
Intranasal Insulin for Posttraumatic Stress Disorder
Phase 2 trial testing Intranasal insulin in PTSD in 20 participants. Currently enrolling.
31 May 2026
Quick facts
| Lead sponsor | VA Connecticut Healthcare System |
|---|---|
| Phase | Phase 2 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 20 |
| Start date | 31 October 2024 |
| Primary completion | 31 May 2026 |
| Estimated completion | 31 May 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Intranasal insulin — full drug profile →
- Placebo
Conditions studied
- PTSD — all drugs for PTSD →
Sponsor
VA Connecticut Healthcare System — full company profile →
Who can join
Adults 21 to 65, any sex, with PTSD. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
To evaluate if intranasal insulin is effective in reducing PTSD symptoms.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Imaging of intranasal drug delivery to the brain.
Veronesi MC, Alhamami M, Miedema SB, Yun Y, et al · · 2020 · cited 63× · PMID 32211216 -
Alleviating anxiety and taming trauma: Novel pharmacotherapeutics for anxiety disorders and posttraumatic stress disorder.
Singewald N, Sartori SB, Reif A, Holmes A. · · 2023 · cited 40× · PMID 36623804 · DOI 10.1016/j.neuropharm.2023.109418
Verify or expand the search:
- PubMed search for NCT04044534
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Intranasal insulin
Trials testing the same drug.
- NCT06072963 — COMMETS- Combination MCI Metabolic Syndrome · Phase 2 · recruiting
- NCT06144255 — Dose-Dependent Effect of Intranasal Insulin in Humans Using Functional Magnetic Resonance Imaging (fMRI) · Phase 1 · completed
- NCT05748990 — Does Abnormal Insulin Action in the Brain Underlie Cognitive and Metabolic Dysfunction in Schizophrenia · NA · recruiting
- NCT05613491 — Intranasal Insulin Improves Postoperative Neurocognitive Disorders in Elderly Patients · NA · unknown
- NCT05062785 — Dose-Finding Study of Intranasal Insulin in Healthy Participants Insulin in Healthy Participants · Phase 1 · completed
Other recruiting trials for PTSD
Currently open trials in the same condition.
- NCT07473505 — Integrative Bilateral Cervical Sympathetic Blocks for Trauma-Related Symptoms in Special Operations Veterans: A Prospect · recruiting
- NCT07010757 — Testing an Integrated PTSD and Weight Management Intervention: A Hybrid Type 1 Trial · NA · recruiting
- NCT07372586 — Behavioral Health Collaborative Care Model in an ICU Recovery Clinic · NA · recruiting
- NCT07390786 — Behavioral Health Collaborative Care Model in Post-ICU Clinic Family Pilot · NA · recruiting
- NCT07469098 — Group vs Individual MDMA-Assisted Therapy for PTSD After the October 7, 2023 Events · Phase 2 · recruiting
Other VA Connecticut Healthcare System trials
Trials by the same sponsor.
- NCT03329157 — Rebuilding Bridges for Homeless Veterans · NA · withdrawn
- NCT05042102 — Donepezil and Cognitive Training for Alcohol Use Disorder (AUD) · Phase 2 · recruiting
- NCT05093556 — Interactive CBT for Headache And Relaxation Training · NA · terminated
- NCT04318639 — The Combination of Donepezil and Cognitive Training for Treating Alcohol Use Disorder · Phase 2, PHASE3 · completed
- NCT02724930 — Cooperative Pain Education and Self-management · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04044534 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by VA Connecticut Healthcare System
- Last refreshed: 16 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04044534.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing