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NCT04041531: 3H-ODC
Triple H ODC Trial
NA trial testing blood sampling in Hypoxia in 30 participants. Completed in 10 February 2020.
30 November 2019
Quick facts
| Lead sponsor | Medical University Innsbruck |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | factorial |
| Masking | single |
| Primary purpose | basic science |
| Enrollment | 30 |
| Start date | 26 August 2019 |
| Primary completion | 30 November 2019 |
| Estimated completion | 10 February 2020 |
| Sites | 1 location across Austria |
Drugs / interventions tested
- blood sampling — full drug profile →
Conditions studied
- Hypoxia — all drugs for Hypoxia →
- Hypothermia, Accidental — all drugs for Hypothermia, Accidental →
- Hypercapnia — all drugs for Hypercapnia →
- Avalanche, Landslide, or Mudslide — all drugs for Avalanche, Landslide, or Mudslide →
Sponsor
Medical University Innsbruck
Who can join
Adults 18 to 40, any sex, with Hypoxia or Hypothermia, Accidental. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In an avalanche burial with an air pocket hypercapnia (and hypoxia) develops within few minutes, hypercapnia increases the rate of cooling and therefore the development of hypothermia. The Triple H Syndrome (Hypoxia, Hypercapnia, Hypothermia) occurs. This specific combination of the three parameters is unique for avalanche burial with an air pocket. Every single parameter has a substantial effect on the hemoglobin-oxygen dissociation curve, but until now no study described the combination of these three parameters. This curve will be measured under these specific conditions in a specifically developed in vitro model, to quantify its shifts and to show if there are combined effects of pCO2 and temperature. The newly developed method will be validated in comparison with an established method. The project will be performed with whole blood, drawn by healthy volunteers, in an experimental setting. The samples will be blinded to the investigator and analyzed in a randomized manner.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effects of Carbon Dioxide and Temperature on the Oxygen-Hemoglobin Dissociation Curve of Human Blood: Implications for Avalanche Victims.
Woyke S, Brugger H, Ströhle M, Haller T, et al · · 2021 · cited 13× · PMID 35198571 · DOI 10.3389/fmed.2021.808025
Verify or expand the search:
- PubMed search for NCT04041531
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04041531 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Medical University Innsbruck
- Last refreshed: 9 September 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04041531.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing