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NCT04040920
Ozone Application Before Fissure Sealants
NA trial testing Ozone in Caries,Dental in 67 participants. Currently enrolling.
31 December 2026
Quick facts
| Lead sponsor | IRCCS Burlo Garofolo |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 67 |
| Start date | 17 June 2019 |
| Primary completion | 31 December 2026 |
| Estimated completion | 31 December 2026 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- Ozone (OZONE) — full drug profile →
- Pits and fissure sealants
Conditions studied
- Caries,Dental — all drugs for Caries,Dental →
Sponsor
IRCCS Burlo Garofolo — full company profile →
Who can join
Adults 6 to 16, any sex, with Caries,Dental. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Decay is a multifactorial infective degenerative disease of hard dental tissues, caused by Streptococcus mutans and Lactobacillus forming the bacterial biofilm of teeth surfaces. Decays generally evolve in fissures and pits of secondary molars. Pits and fissure sealants prevent decays if performed in two years from eruption. Ozone has bactericidal effect and remineralizing capacity on enamel. The aim of this study is to assess the effectiveness of ozone application before sealants in increasing their duration in time.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT04040920
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Ozone
Trials testing the same drug.
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- NCT05794087 — The Role of Macrophage Activation in Lung Injury Following Ozone Exposure · NA · recruiting
- NCT06909305 — Effect of Intraarticular Ozone, Prolotherapy or Dexmedetomidine in Pain Limitation in Knee Osteoarthritis · NA · completed
- NCT05473000 — Susceptibility of Cardiorespiratory Responses to Ozone During Cycling Exercise · NA · completed
Other recruiting trials for Caries,Dental
Currently open trials in the same condition.
- NCT07323433 — Efficacy of a Chitosan Dressing in Pulpotomy of Immature Permanent Teeth · NA · recruiting
- NCT06690229 — Evaluation of Different Cementation Materials Used in Prefabricated Pediatric Zirconia Crowns · NA · active not recruiting
- NCT06453005 — Comparative Evaluation of SMART Hall Technique Vs. Conventional SS Crown in Primary Molars: a Randomized Clinical Trial · NA · recruiting
- NCT05860712 — Evaluation of Antimicrobial, Post Operative Pain of Cinnamon Extract Versus Sodium Hypochlorite Irrigant Following Pulpe · NA · recruiting
- NCT05969756 — Early Treatments for Preventing Occlusal Caries Lesions · NA · active not recruiting
Other IRCCS Burlo Garofolo trials
Trials by the same sponsor.
- NCT06895278 — Articular Damage in Patients With Juvenile Idiopathic Arthritis After Transition to Adult Care · not yet recruiting
- NCT05821569 — Cerebral Synchronization Between Mothers and Their Newborns During Breastfeeding · unknown
- NCT06310421 — Spinal Muscular Atrophy Neonatal Screening Program · recruiting
- NCT05806372 — Biomarkers of CVD Dysfunction in Hypertensive Disorders of Pregnancy · unknown
- NCT06324578 — Prevalence of Pre-clinical Sjögren Disease and Other Immune Disturbances in Subjects With Autoimmune Thyroiditis Disease · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04040920 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by IRCCS Burlo Garofolo
- Last refreshed: 16 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04040920.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing