NCT04035759 is a Phase 1 clinical trial of APPEAL in HIV/AIDS, sponsored by State University of New York - Downstate Medical Center.

Who is sponsoring NCT04035759?

NCT04035759 is sponsored by State University of New York - Downstate Medical Center.

What drugs are being tested in NCT04035759?

Interventions in NCT04035759: APPEAL.

Is NCT04035759 still recruiting?

NCT04035759 is currently completed. Last updated 1 November 2021.

Last reviewed 2021-11-01 · How we verify

NCT04035759

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Positive Affect Promotion to Empower Optimal Adherence to HIV Therapy

Completed Phase 1 Last updated 1 November 2021

What this trial tests

Phase 1 trial testing APPEAL in HIV/AIDS in 20 participants. Completed in 26 April 2021.

Timeline

16 October 2019

Primary endpoint
26 April 2021

26 April 2021

Quick facts

Lead sponsor	State University of New York - Downstate Medical Center
Phase	Phase 1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	prevention
Enrollment	20
Start date	16 October 2019
Primary completion	26 April 2021
Estimated completion	26 April 2021
Sites	1 location across United States

Drugs / interventions tested

APPEAL

Conditions studied

HIV/AIDS — all drugs for HIV/AIDS →

Sponsor

State University of New York - Downstate Medical Center

Who can join

18 and older, any sex, with HIV/AIDS. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study assesses the feasibility and acceptability of the APPEAL program, a 3-session intervention designed to promote positive affect among men and women living with HIV infection. Forty participants will be randomly assigned to receive the APPEAL program, and another 40 will receive standard of care. All participants will complete self-reported assessments at baseline and at 3 and 6 months, and will have their HIV antiretroviral medication adherence monitored as part of study participation.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Accuracy of measures for antiretroviral adherence in people living with HIV.
Smith R, Villanueva G, Probyn K, Sguassero Y, et al · · 2022 · cited 34× · PMID 35871531 · DOI 10.1002/14651858.cd013080.pub2
The positive affect, promoting Positive Engagement, and Adherence for Life (APPEAL) feasibility trial: Design and rationale.
Wilson TE, Massiah C, Radigan R, DeHovitz J, et al · · 2020 · cited 3× · PMID 32833478 · DOI 10.1037/hea0000880

Verify or expand the search:

Other recruiting trials for HIV/AIDS

Currently open trials in the same condition.

NCT06741618 — MyPEEPS Mobile Plus: A Multi-Level HIV Prevention Intervention for Young MSM · NA · recruiting
NCT07298785 — Peer-led Dynamic Choice HIV Prevention for Women: The Peer-led DCP Pilot Study · NA · recruiting
NCT07072481 — Sustaining Innovative Tools to Expand Youth-Friendly HIV Self-Testing · NA · recruiting
NCT07064785 — Video-Intervention to Inspire Treatment Adherence for Life for Adolescents · NA · recruiting
NCT07074899 — Evaluation of a Multi-Component Intervention to Support HIV Testing and Linkage to Services Among MSM in Peru · NA · active not recruiting

Other State University of New York - Downstate Medical Center trials

Trials by the same sponsor.

NCT06119152 — Digital Equity for Stroke Approach · NA · unknown
NCT05796167 — Pimavanserin for Sleep in Parkinson Disease · EARLY_PHASE1 · withdrawn
NCT04755595 — Combination Facial Aesthetic Treatment in Millennials · Phase 2 · completed
NCT05439772 — Examining the Effect of Ondansetron on Bowel Prep Success · Phase 4 · completed
NCT05071378 — Leveraging Family-Based Assets for Black MSM In House Ball Communities · NA · unknown

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04035759 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by State University of New York - Downstate Medical Center
Last refreshed: 1 November 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04035759.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing