NCT04032730 (PRAXIS) is a NA clinical trial of Wisepill device in Adherence, Patient, sponsored by Centre for the AIDS Programme of Research in South Africa.

Who is sponsoring NCT04032730?

NCT04032730 is sponsored by Centre for the AIDS Programme of Research in South Africa.

What drugs are being tested in NCT04032730?

Interventions in NCT04032730: Wisepill device.

What condition does NCT04032730 study?

NCT04032730 studies Adherence, Patient.

Is NCT04032730 still recruiting?

NCT04032730 is currently completed. Last updated 8 February 2023.

Last reviewed 2023-02-08 · How we verify

NCT04032730: PRAXIS

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Promoting Engagement in the Drug Resistant TB-HIV Care Continuum in South Africa PRAXIS Study

Completed NA Last updated 8 February 2023

What this trial tests

NA trial testing Wisepill device in Adherence, Patient in 171 participants. Completed in 5 December 2022.

Timeline

29 April 2018

Primary endpoint
28 September 2021

5 December 2022

Quick facts

Lead sponsor	Centre for the AIDS Programme of Research in South Africa
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	supportive care
Enrollment	171
Start date	29 April 2018
Primary completion	28 September 2021
Estimated completion	5 December 2022
Sites	1 location across South Africa

Drugs / interventions tested

Wisepill device

Conditions studied

Adherence, Patient — all drugs for Adherence, Patient →

Sponsor

Centre for the AIDS Programme of Research in South Africa — full company profile →

Who can join

Adults 18 to 70, any sex, with Adherence, Patient. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of the proposed study is to enhance adherence and retention in care for M/XDR-TB HIV patients through enhanced standard of care, targeted transition to outpatient medication self-administration prior to hospital discharge, and use of community adherence groups, with an overarching goal of promoting patient engagement in a care continuum.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Population-level emergence of bedaquiline and clofazimine resistance-associated variants among patients with drug-resistant tuberculosis in southern Africa: a phenotypic and phylogenetic analysis.
Nimmo C, Millard J, van Dorp L, Brien K, et al · · 2020 · cited 88× · PMID 32803174 · DOI 10.1016/s2666-5247(20)30031-8
Differentiated service delivery framework for people with multidrug-resistant tuberculosis and HIV co-infection.
Reis K, Wolf A, Perumal R, Seepamore B, et al · · 2024 · cited 1× · PMID 38323838 · DOI 10.1097/qai.0000000000003394
Body mass index (BMI) at RR-TB diagnosis as an independent predictor of treatment outcomes: a retrospective analysis.
Mzinyane N, Perumal R, Amusa LB, Chetty D, et al · · 2026 · PMID 41877080 · DOI 10.1186/s12879-026-13121-z

Verify or expand the search:

Other recruiting trials for Adherence, Patient

Currently open trials in the same condition.

NCT07261553 — Adherence to Home-Based Exercises in Musculoskeletal Disorders · recruiting
NCT05613010 — Leveraging Technology to Improve Medication Adherence in Youth With Kidney or Liver Transplant · NA · recruiting
NCT05832008 — Increasing Adherence to Lung Cancer Screening · NA · active not recruiting
NCT05448560 — A Multilevel Intervention to Improve Adherence to Childhood Cancer Survivorship · NA · active not recruiting
NCT04298905 — Leveraging mHealth to Enable and Adapt CHW Strategies to Improve TB/HIV Patient Outcomes in SA · NA · active not recruiting

Other Centre for the AIDS Programme of Research in South Africa trials

Trials by the same sponsor.

NCT05175794 — Triage Test for All Oral DR-TB Regimen (TRiAD Study) · completed
NCT04734652 — INSTI's For The Management of HIV-associated TB · Phase 2 · completed
NCT03237182 — The Individualized M(X) Drug-resistant TB Treatment Strategy Study · Phase 4 · terminated
NCT03407586 — STI Care Model to Reduce Genital Inflammation and HIV Risk in South African Women · NA · completed
NCT02654613 — Scaling up TB and HIV Treatment Integration · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04032730 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Centre for the AIDS Programme of Research in South Africa
Last refreshed: 8 February 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04032730.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing