NCT04030286 is a clinical trial of Observation in Metabolic Disease, sponsored by University of Messina.

Who is sponsoring NCT04030286?

NCT04030286 is sponsored by University of Messina.

What drugs are being tested in NCT04030286?

Interventions in NCT04030286: Observation.

What condition does NCT04030286 study?

NCT04030286 studies Metabolic Disease.

Is NCT04030286 still recruiting?

NCT04030286 is currently completed. Last updated 23 July 2019.

Last reviewed 2019-07-23 · How we verify

NCT04030286

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Evaluation of Malondialdehyde in Periodontal and Cardiovascular Disease

Completed Last updated 23 July 2019

What this trial tests

trial testing Observation in Metabolic Disease in 133 participants. Completed in 1 April 2019.

Timeline

3 January 2014

Primary endpoint
9 September 2018

1 April 2019

Quick facts

Lead sponsor	University of Messina
Status	Completed
Study type	OBSERVATIONAL
Enrollment	133
Start date	3 January 2014
Primary completion	9 September 2018
Estimated completion	1 April 2019
Sites	1 location across Italy

Drugs / interventions tested

Observation

Conditions studied

Metabolic Disease — all drugs for Metabolic Disease →

Sponsor

University of Messina

Who can join

Adults 20 to 70, any sex, with Metabolic Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Malondialdehyde (MDA) plays a key role in endothelial function and may be a link for the known interaction of periodontitis and coronary heart disease (CHD). The investigators compared the impact of gingival health, periodontitis (CP), CHD or of both diseases (CP+CHD) on saliva and serum MDA levels.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Expression of Salivary and Serum Malondialdehyde and Lipid Profile of Patients with Periodontitis and Coronary Heart Disease.
Isola G, Polizzi A, Santonocito S, Alibrandi A, et al · · 2019 · cited 44× · PMID 31805680 · DOI 10.3390/ijms20236061
Advancements and Challenges in Salivary Metabolomics for Early Detection and Monitoring of Systemic Diseases.
Zhao X, Chen X, Zhou Z, Zheng J, et al · · 2025 · cited 1× · PMID 40989572 · DOI 10.1002/mco2.70395

Verify or expand the search:

Other trials of Observation

Trials testing the same drug.

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Other recruiting trials for Metabolic Disease

Currently open trials in the same condition.

NCT06575426 — A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes M · Phase 1, PHASE2 · recruiting
NCT06938386 — Pilot Haskap Metabolite Timing Project · NA · active not recruiting
NCT06954298 — Molecular Landscape of Complex Lifestyle Modification · NA · active not recruiting
NCT06717581 — Variation in Drug Interactions in People With HIV (PLWH) Aged 60 Years and Older. · recruiting
NCT06529965 — Evaluating a Digital Intervention for Alleviating Diabetes-specific Emotional Distress in Adults Living With T2DM · NA · recruiting

Other University of Messina trials

Trials by the same sponsor.

NCT07106463 — Microbiota: Its Role in Chronic Inflammation, IDB and Risk of Colorectal Cancer. Evaluation of a Predictive Prognostic M · active not recruiting
NCT05496322 — Continuous Vs Intermittent Non Invasive Blood Pressure Monitoring in Preventing Post Operative Organ Failure · NA · completed
NCT05122741 — Modulation of Fibrosis-inducing Pathways in Acute Myocardial Infarction · unknown
NCT04994379 — Investigating the Effects of Intensity of Transcranial Direct Current Stimulation on Subjective Appetite · NA · terminated
NCT06787781 — Metabolic and Clinical Effect of Alpha-lipoic Acid Administration in Schizophrenic Subjects · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04030286 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Messina
Last refreshed: 23 July 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04030286.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing