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NCT04028882: MetACTIVIH
Immune Activation as a Cause of Insulin Resistance in Adults Living With HIV-1 on Effective Antiretroviral Therapy
trial testing Signaling, metabolomic and transcriptomic analysis in HIV Infections in 148 participants. Terminated before completion.
9 February 2024
Quick facts
| Lead sponsor | University Hospital, Montpellier |
|---|---|
| Status | Terminated |
| Study type | OBSERVATIONAL |
| Enrollment | 148 |
| Start date | 3 March 2020 |
| Primary completion | 9 February 2024 |
| Estimated completion | 9 February 2024 |
| Sites | 1 location across France |
Drugs / interventions tested
- Signaling, metabolomic and transcriptomic analysis
Conditions studied
- HIV Infections — all drugs for HIV Infections →
Sponsor
University Hospital, Montpellier
Who can join
18 and older, any sex, with HIV Infections. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of this study is to characterize in non-viremic HIV-1 patients under antiretroviral therapy an immune activation profile that the investigators have previously shown to be strongly linked to hyperinsulinemia. This characterization will be carried out via 3 different approaches. First, the investigators will analyze the metabolites present in the plasma of patients presenting with the profile of interest. Second, the investigators will study the transcriptome of the peripheral blood mononuclear cells of these patients. Finally, the investigators will search whether some factors released by these cells are able to induce insulin resistance. In addition the ability of the profile of interest to predict an increase in insulinemia over time will be assessed.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Identification of distinct immune activation profiles in adult humans.
Cezar R, Winter A, Desigaud D, Pastore M, et al · · 2020 · cited 3× · PMID 33257766 · DOI 10.1038/s41598-020-77707-6 -
Insulin resistance is linked to a specific profile of immune activation in human subjects.
Cezar R, Desigaud D, Pastore M, Kundura L, et al · · 2021 · cited 2× · PMID 34112902 · DOI 10.1038/s41598-021-91758-3 -
γ-Aminobutyric Acid-Induced Monocytic Reactive Oxygen Species Impair CD4 Restoration in Treated Adults With HIV-1.
Younas M, Gimenez S, Lin YL, Mettling C, et al · · 2025 · cited 1× · PMID 39903648 · DOI 10.1093/infdis/jiaf058
Verify or expand the search:
- PubMed search for NCT04028882
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04028882 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Montpellier
- Last refreshed: 6 August 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04028882.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing