NCT04027452

Electroconvulsive Therapy for Traumatic Memories

Completed NA Last updated 3 September 2020

What this trial tests

NA trial testing Traumatic memory reactivation in Post Traumatic Stress Disorder in 28 participants. Completed in 1 July 2020.

Timeline

7 January 2016

Primary endpoint
1 July 2020

1 July 2020

Quick facts

Lead sponsor	Centre for Addiction and Mental Health
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	28
Start date	7 January 2016
Primary completion	1 July 2020
Estimated completion	1 July 2020
Sites	1 location across Canada

Drugs / interventions tested

• Traumatic memory reactivation
• Neutral memory reactivation

Conditions studied

• Post Traumatic Stress Disorder — all drugs for Post Traumatic Stress Disorder →
• Depression — all drugs for Depression →

Sponsor

Centre for Addiction and Mental Health — full company profile →

Who can join

18 and older, any sex, with Post Traumatic Stress Disorder or Depression. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study will investigate whether ECT treatment can reduce the effect of traumatic memories if those memories are recalled immediately prior to the ECT sessions. Participants will be randomized to either a recall of a traumatic memory or a neutral non-traumatic memory prior to their ECT sessions.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Electroconvulsive therapy with a memory reactivation intervention for post-traumatic stress disorder: A randomized controlled trial.
   Tang VM, Trought K, Gicas KM, Kozak M, et al · · 2021 · cited 15× · PMID 33785406 · DOI 10.1016/j.brs.2021.03.015
2. Electroconvulsive Therapy with a Memory Reactivation Intervention for Post-Traumatic Stress Disorder: A Randomized Controlled Trial
   Tang VM, Trought K, Gicas KM, Kozak M, et al · · 2020 · DOI 10.1101/2020.10.10.20210450