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Combined Treatment of Angiotensin Receptor Blocker and Antioxidant Supplementation as a Novel Adjunctive Therapy for 24-hour Blood Pressure Improvement in Obstructive Sleep Apnea
This study examines the combined effects of an angiotensin receptor blocker (ARB), antioxidant supplementation, and continuous positive airway pressure (CPAP) therapy on the lowering of 24-hour blood pressure in persons with moderate to severe Obstructive Sleep Apnea (OSA). All participants will undergo CPAP therapy as prescribed by their doctor; however, half of the participants will receive the combined ARB and antioxidant treatment while the other half of the participants will receive a placebo.
Details
| Lead sponsor | University of British Columbia |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | WITHDRAWN |
| Start date | 2023-05 |
| Completion | 2026-12 |
Conditions
- Obstructive Sleep Apnea
Interventions
- Continuous Positive Airway Pressure CPAP
- Telmisartan 80mg
- Alpha-Lipoic Acid 600mg
- Microcrystalline Cellulose
Primary outcomes
- Change in 24-hour blood pressure — Change from baseline of 24-hour systolic, diastolic, and mean arterial blood pressure at 6 weeks
Systolic, diastolic, and mean arterial blood pressure (mmHg)