NCT04018456 is a NA clinical trial of Biodentine in Necrotic Pulp, sponsored by Cairo University.

Who is sponsoring NCT04018456?

NCT04018456 is sponsored by Cairo University.

What drugs are being tested in NCT04018456?

Interventions in NCT04018456: Biodentine, White MTA.

What condition does NCT04018456 study?

NCT04018456 studies Necrotic Pulp, Apical Periodontitis.

Is NCT04018456 still recruiting?

NCT04018456 is currently completed. Last updated 23 January 2024.

Last reviewed 2024-01-23 · How we verify

NCT04018456

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Regenerative Endodontic Treatment of Mature Necrotic Teeth With Apical Periodontitis

Completed NA Last updated 23 January 2024

What this trial tests

NA trial testing Biodentine in Necrotic Pulp in 36 participants. Completed in 1 June 2023.

Timeline

1 August 2021

Primary endpoint
1 January 2022

1 June 2023

Quick facts

Lead sponsor	Cairo University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	36
Start date	1 August 2021
Primary completion	1 January 2022
Estimated completion	1 June 2023
Sites	1 location across Egypt

Drugs / interventions tested

Biodentine — full drug profile →
White MTA — full drug profile →

Conditions studied

Necrotic Pulp — all drugs for Necrotic Pulp →
Apical Periodontitis — all drugs for Apical Periodontitis →

Sponsor

Cairo University

Who can join

Adults 10 to 45, any sex, with Necrotic Pulp or Apical Periodontitis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aim of this prospective, randomized, controlled double-blind study is to evaluate the effectiveness of biodentine compared with MTA used as pulp space barrier on discoloration of teeth after regenerative based non-obturation root canal treatment in mature single canal with pulp necrosis and apical periodontitis.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Regenerative Treatment of Mature Teeth with Pulp Necrosis and Apical Periodontitis Using Biodentine Compared with MTA: Randomized Controlled Clinical Trial.
Al-Rawhani AH, Ibrahim SM, Abu Naeem FM. · · 2024 · cited 2× · PMID 39475095 · DOI 10.14744/eej.2024.30075

Verify or expand the search:

Other trials of Biodentine

Trials testing the same drug.

NCT06683833 — Comparison Between Egyptian MTA, Biodentine Versus Calcium Hydroxide as Indirect Pulp Capping Materials In Permanent Tee · Phase 4 · recruiting
NCT07130214 — The Effect of Genetic Polymorphisms on the Success of Vital Pulp Therapy · active not recruiting
NCT06695208 — Socket Preservation Using Biodentin Versus Xeno Graft for Single Rooted Teeth · Phase 4 · recruiting
NCT05937100 — New Vital Pulpotomy Medications in Primary Molars · NA · active not recruiting
NCT06020911 — Indirect Pulp Capping Using Biodentine and Theracal Light-cured in Primary Molars · Phase 4 · completed

Other recruiting trials for Necrotic Pulp

Currently open trials in the same condition.

NCT07310212 — Evaluation of Postoperative Pain and Success Rate Between Lateral Condensation and Warm Vertical Obturation Techniques · NA · recruiting

Other Cairo University trials

Trials by the same sponsor.

NCT04155528 — Effect of Music Therapy on Postoperative Health Outcomes · NA · not yet recruiting
NCT07363239 — CBCT-Based Safety Distance for Implant Placement Near the Inferior Alveolar Canal · not yet recruiting
NCT07374575 — Egyptian Dental Professionals' Perspectives on the Oral Microbiome and Exosomes · not yet recruiting
NCT07381153 — In-Vitro Cytotoxicity Assessment of INOX (Nanoksa G Plus) Polymer Discs · not yet recruiting
NCT07375394 — 3D-Printed Extraoral Camera for Standardized Dental Photography · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04018456 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Cairo University
Last refreshed: 23 January 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04018456.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing