NCT04016909

The Effect of Combined Aerobic Exercise and Calorie Restriction on Mood, Cognition, and Motor Behavior in Overweight and Obese Women

Completed NA Last updated 10 December 2019

What this trial tests

NA trial testing aerobic exercise plus calorie restriction in Obesity in 26 participants. Completed in 31 July 2019.

Timeline

1 October 2018

Primary endpoint
15 June 2019

31 July 2019

Quick facts

Lead sponsor	Lithuanian Sports University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	26
Start date	1 October 2018
Primary completion	15 June 2019
Estimated completion	31 July 2019
Sites	1 location across Lithuania

Drugs / interventions tested

• aerobic exercise plus calorie restriction

Conditions studied

• Obesity — all drugs for Obesity →
• Metabolic Syndrome — all drugs for Metabolic Syndrome →

Sponsor

Lithuanian Sports University

Who can join

Adults 35 to 55, female only, with Obesity or Metabolic Syndrome. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The benefits of weight-loss programs on mood state and cognitive and motor behavior remain unclear and are largely limited to those of calorie restriction (CR) or physical exercise alone. Our aim was to investigate the effect of a combined CR and aerobic exercise program on mood state, cognition-related brain activity, and cognitive and motor behavior in overweight and obese women. Twenty-six overweight or obese women were randomized to either a control group (no intervention) or an experimental group (aerobic exercise + 12.5% energy-intake reduction). Brain-derived neurotrophic factor (BDNF) levels, mood, prefrontal cortex activity, cognitive performance, and learning of a speed-accuracy task were evaluated before and 6 months after the beginning of the program. Confusion and depression increased in the control group (P \< 0.05), whereas tension decreased in the experimental group (P \< 0.05). BDNF level and learning of a speed-accuracy task remained unchanged. Although PFC activity and executive functions were not affected, the reaction time of visual scanning and associative learning were improved in the experimental group (P \< 0.05). An improvement in reaction time during the speed-accuracy task was observed (P \< 0.05). In conclusion, a 6-month combined CR and aerobic exercise intervention improved the psychosocial mental state of overweight and obese women. Although it improved motor planning during the speed-accuracy task, it had little impact on cognition and no effect on brain activity and learning of the speed-accuracy task.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.