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NCT04016181: ELFMEN
The Edinburgh Lung Fibrosis Molecular Endotyping (ELFMEN) Study
trial in Idiopathic Pulmonary Fibrosis in 800 participants. Enrolling by invitation.
31 December 2026
Quick facts
| Lead sponsor | University of Edinburgh |
|---|---|
| Status | ENROLLING BY INVITATION |
| Study type | OBSERVATIONAL |
| Enrollment | 800 |
| Start date | 14 June 2007 |
| Primary completion | 31 December 2026 |
| Estimated completion | 1 December 2036 |
Conditions studied
- Idiopathic Pulmonary Fibrosis — all drugs for Idiopathic Pulmonary Fibrosis →
- Interstitial Lung Disease — all drugs for Interstitial Lung Disease →
- Asbestosis — all drugs for Asbestosis →
Sponsor
University of Edinburgh
Who can join
Adults 18 to 99, any sex, with Idiopathic Pulmonary Fibrosis or Interstitial Lung Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
To prospectively study novel blood and lung biomarkers of disease activity in patients with IPF and other interstitial lung disease with the aims of prognostic modelling and disease clustering
Publications & conference data
5 peer-reviewed publications reference this trial (live from Europe PMC):
-
Genome-wide association study across five cohorts identifies five novel loci associated with idiopathic pulmonary fibrosis.
Allen RJ, Stockwell A, Oldham JM, Guillen-Guio B, et al · · 2022 · cited 108× · PMID 35688625 · DOI 10.1136/thoraxjnl-2021-218577 -
Distinct Exosomal miRNA Profiles from BALF and Lung Tissue of COPD and IPF Patients.
Kaur G, Maremanda KP, Campos M, Chand HS, et al · · 2021 · cited 58× · PMID 34769265 · DOI 10.3390/ijms222111830 -
Longitudinal lung function and gas transfer in individuals with idiopathic pulmonary fibrosis: a genome-wide association study.
Allen RJ, Oldham JM, Jenkins DA, Leavy OC, et al · · 2023 · cited 50× · PMID 35985358 · DOI 10.1016/s2213-2600(22)00251-x -
Genome-wide association study of Idiopathic Pulmonary Fibrosis susceptibility using clinically-curated European-ancestry datasets
Chin D, Hernandez-Beeftink T, Donoghue L, Guillen-Guio B, et al · · 2025 · DOI 10.1101/2025.01.30.25321017 -
Genome-wide SNP-sex interaction analysis of susceptibility to idiopathic pulmonary fibrosis
Leavy OC, Goemans AF, Stockwell AD, Allen RJ, et al · · 2024 · DOI 10.1101/2024.01.12.24301204
Verify or expand the search:
- PubMed search for NCT04016181
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Idiopathic Pulmonary Fibrosis
Currently open trials in the same condition.
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- NCT07036523 — A Study to Find Out Whether BI 765423 Has an Effect on Lung Function in People With Idiopathic Pulmonary Fibrosis (IPF) · Phase 2 · recruiting
- NCT07225296 — A Single and Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics o · Phase 1 · recruiting
Other University of Edinburgh trials
Trials by the same sponsor.
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- NCT07430540 — Optimising Colorectal Cancer Patient Pathways · NA · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04016181 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Edinburgh
- Last refreshed: 25 June 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04016181.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing