NCT04012749 is a NA clinical trial of Advance directive in Advance Care Planning, sponsored by University of California, Los Angeles.

Who is sponsoring NCT04012749?

NCT04012749 is sponsored by University of California, Los Angeles.

What drugs are being tested in NCT04012749?

Interventions in NCT04012749: Advance directive, Prepare, Facilitator.

What condition does NCT04012749 study?

NCT04012749 studies Advance Care Planning, Advance Directives, Advanced Cancer.

Is NCT04012749 still recruiting?

NCT04012749 is currently completed. Last updated 13 May 2025.

Last reviewed 2025-05-13 · How we verify

NCT04012749

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

UC Health Care Planning Study

Completed NA Last updated 13 May 2025

What this trial tests

NA trial testing Advance directive in Advance Care Planning in 8,707 participants. Completed in 15 September 2024.

Timeline

25 October 2019

Primary endpoint
30 June 2022

15 September 2024

Quick facts

Lead sponsor	University of California, Los Angeles
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	supportive care
Enrollment	8,707
Start date	25 October 2019
Primary completion	30 June 2022
Estimated completion	15 September 2024
Sites	3 locations across United States

Drugs / interventions tested

Advance directive
Prepare
Facilitator

Conditions studied

Advance Care Planning — all drugs for Advance Care Planning →
Advance Directives — all drugs for Advance Directives →
Advanced Cancer — all drugs for Advanced Cancer →

Sponsor

University of California, Los Angeles

Who can join

18 and older, any sex, with Advance Care Planning or Advance Directives. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Using a cluster randomized design at the clinic level, this project will implement and test three real-world, scalable advance care planning interventions among primary care clinics across three University of California health systems. Seriously ill patients identified using data from the electronic health record will receive (1) an advance directive with targeted messaging, (2) intervention 1 plus prompting to engage with the Prepare For Your Care website, or (3) intervention 2 plus engagement from a clinic-based facilitator. A Research cohort of patients will provide complete surveys at baseline, 12 and 24 months. The main outcomes are advance directive completion among the population cohort and goal concordant care among the Research cohort at 12 months.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Support for Use of Consumer Assessment of Healthcare Providers and Systems Communication Items Among Seriously Ill Patients.
Hays RD, Walling AM, Sudore RL, Chau A, et al · · 2023 · cited 4× · PMID 37093298 · DOI 10.1089/jpm.2022.0572
Advance Directive Completion Among Community-Dwelling Adults with Decompensated Cirrhosis.
Patel AA, Walling AM, Sudore RL, Tseng CH, et al · · 2025 · cited 1× · PMID 41455037 · DOI 10.1007/s10620-025-09616-5
Interventions to Improve Advance Care Planning Documentation in the Electronic Health Record : A Cluster Randomized Trial.
Walling AM, Sudore RL, Gibbs L, Rahimi M, et al · · 2026 · cited 1× · PMID 41285010 · DOI 10.7326/annals-25-02111
Standard HIPAA Authorization Forms Decreased Response Rates for a Multi-site Pragmatic Trial.
Walling AM, Wenger NS, Chau AJ, Reihm J, et al · · 2025 · PMID 39438380 · DOI 10.1007/s11606-024-09074-1

Verify or expand the search:

Other recruiting trials for Advance Care Planning

Currently open trials in the same condition.

NCT07235839 — The Impact of an Advance Care Planning Game on Life-Sustaining Treatment Preferences, Depression, and Hope in Older Adul · NA · active not recruiting
NCT07134881 — Navigating Advanced Illness Goals And Treatment With Digital Engagement (NAVIGATE) · NA · recruiting
NCT06538493 — Jumpstarting Advance Care Planning With ANAI People · NA · recruiting
NCT06731361 — Improved Prescribing for Older Nursing Home Patients · NA · recruiting
NCT06376799 — Which Health-care Professional(s) to Talk About Advance Care Planning ? · recruiting

Other University of California, Los Angeles trials

Trials by the same sponsor.

NCT04846517 — rTMS for Aneroxia Nervosa in Youth · NA · not yet recruiting
NCT06701760 — Sodium Lactate in Severe TBI · Phase 2 · not yet recruiting
NCT04996667 — Effect of iNO in Patients With Submassive and Massive PE · Phase 2 · withdrawn
NCT05067387 — Evaluation of Oral THC and CBD in Men and Women · Phase 1 · not yet recruiting
NCT07534696 — Evaluation of Non-Invasive Pelvic Floor Neuromuscular Stimulation for Urinary Incontinence After Prostatectomy · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04012749 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of California, Los Angeles
Last refreshed: 13 May 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04012749.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing