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NCT04012424
The Effect of Premedication With Curcumin on Post-endodontic Pain
NA trial testing curcumin group:Curcumin is an ancient coloring spice . Interestingly, it has various pharmacological activities including analgesic, anti-inf in Acute Pulpitis in 44 participants. Completed in 1 November 2020.
1 August 2020
Quick facts
| Lead sponsor | Cairo University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 44 |
| Start date | 1 August 2019 |
| Primary completion | 1 August 2020 |
| Estimated completion | 1 November 2020 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- curcumin group:Curcumin is an ancient coloring spice . Interestingly, it has various pharmacological activities including analgesic, anti-inf
- 400mg starch
Conditions studied
- Acute Pulpitis — all drugs for Acute Pulpitis →
Sponsor
Cairo University
Who can join
Adults 22 to 55, any sex, with Acute Pulpitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Will premedication with Curcumin in single endodontic treatment in patients having acute pulpitis in mandibular molars affect post- operative pain? This the present study hopes to bring an evidence based decision on the possibility of using curcumin as a premedication to reduce post-operative pain in single visit treatment of cases with acute pulpitis
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Reconnoitering the Therapeutic Role of Curcumin in Disease Prevention and Treatment: Lessons Learnt and Future Directions.
Sivani BM, Azzeh M, Patnaik R, Pantea Stoian A, et al · · 2022 · cited 26× · PMID 35888763 · DOI 10.3390/metabo12070639
Verify or expand the search:
- PubMed search for NCT04012424
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Acute Pulpitis
Currently open trials in the same condition.
- NCT06526572 — Pain Measured by NRS and EEG in Acute Pulpitis · recruiting
Other Cairo University trials
Trials by the same sponsor.
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- NCT07374575 — Egyptian Dental Professionals' Perspectives on the Oral Microbiome and Exosomes · not yet recruiting
- NCT07381153 — In-Vitro Cytotoxicity Assessment of INOX (Nanoksa G Plus) Polymer Discs · not yet recruiting
- NCT07375394 — 3D-Printed Extraoral Camera for Standardized Dental Photography · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04012424 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Cairo University
- Last refreshed: 13 August 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04012424.
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