NCT04010253 (MUCOSIM) is a NA clinical trial of SIMEOX in Cystic Fibrosis, sponsored by Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche.

What drugs are being tested in NCT04010253?

Interventions in NCT04010253: SIMEOX, Autogenic drainage.

What condition does NCT04010253 study?

NCT04010253 studies Cystic Fibrosis.

Is NCT04010253 still recruiting?

NCT04010253 is currently completed. Last updated 18 March 2026.

Last reviewed 2026-03-18 · How we verify

NCT04010253: MUCOSIM

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Impact of Bronchial Drainage Technique by the Medical Device Simeox® on Respiratory Function and Symptoms in Adult Patients With Cystic Fibrosis

Completed NA Last updated 18 March 2026

What this trial tests

NA trial testing SIMEOX in Cystic Fibrosis in 31 participants. Completed in 13 December 2023.

Timeline

30 September 2019

Primary endpoint
13 December 2023

13 December 2023

Quick facts

Lead sponsor	Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	treatment
Enrollment	31
Start date	30 September 2019
Primary completion	13 December 2023
Estimated completion	13 December 2023
Sites	8 locations across France

Drugs / interventions tested

SIMEOX
Autogenic drainage

Conditions studied

Cystic Fibrosis — all drugs for Cystic Fibrosis →

Sponsor

Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche

Who can join

18 and older, any sex, with Cystic Fibrosis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The main objective of the study is to evaluate the short-term effects of the airway clearance technique by the medical device Simeox (Physio Assist, France) versus Autogenic Drainage, on the pulmonary function of adult patients with stable cystic fibrosis. To analyse these effects, the investigators used forced oscillation technique measured by TremoFlo™ C-100 Airwave Oscillometry System™ (THORASYS Thoracic Medical Systems Inc. Montreal, Quebec, Canada) with an evaluation of the perceived clinical benefits.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Autogenic drainage for airway clearance in cystic fibrosis.
Burnham P, Stanford G, Stewart R. · · 2021 · cited 14× · PMID 34910295 · DOI 10.1002/14651858.cd009595.pub3
Airway clearance techniques compared to no airway clearance techniques for cystic fibrosis.
Warnock L, Gates A. · · 2023 · cited 12× · PMID 37042825 · DOI 10.1002/14651858.cd001401.pub4

Verify or expand the search:

Other trials of SIMEOX

Trials testing the same drug.

NCT04096664 — Home Airway Clearance in CF Patients · NA · completed
NCT04095078 — Ancillary Home Airway Clearance in CF Patients ( HomeCareSIMEOX ) · NA · completed
NCT04157972 — Effects of SIMEOX on Static Hyperinflation in Patients With COPD · NA · completed
NCT04150601 — Effects of SIMEOX on Flow and Volume in Healthy Subjects and Patients With COPD · NA · completed
NCT03655860 — Effects of SIMEOX on Flow and Volume · NA · withdrawn

Other recruiting trials for Cystic Fibrosis

Currently open trials in the same condition.

NCT07437105 — Dose Escalation Study Evaluating the Safety and Pharmacokinetics of VX-272 in Healthy Participants · Phase 1 · recruiting
NCT07283770 — Dose Escalation Study Evaluating the Safety and Pharmacokinetics of VX-581 in Healthy Participants · Phase 1 · recruiting
NCT07274631 — A Cohort for Inflammatory Respiratory Diseases: From Phenotyping to Personalised Medicine · recruiting
NCT06810167 — Assessing Tenapanor as a Treatment of CF-related Constipation. · Phase 3 · recruiting
NCT06962852 — A Long-term Study to Monitor the Health Status of People With Cystic Fibrosis Who Took Part in a Previous Study With BI · Phase 1, PHASE2 · active not recruiting

Other Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche trials

Trials by the same sponsor.

NCT05815420 — Home Tele-Monitoring of Non-Invasive Ventilation in COPD Patients in France · unknown
NCT03395418 — Evaluation of the Right Use of Inhaled Therapeutics · completed
NCT03053011 — Evaluation of the Awakening Capability by a Vibrating Bracelet (BRASSARD) · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04010253 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche
Last refreshed: 18 March 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04010253.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing