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NCT04008173: ISACS-ARCHIVES
The International Survey of Acute Coronary Syndromes-ARCHIVES
trial testing Non-interventional patient registry in Acute Coronary Syndrome in 130,000 participants. Enrolling by invitation.
31 December 2025
Quick facts
| Lead sponsor | University of Bologna |
|---|---|
| Status | ENROLLING BY INVITATION |
| Study type | OBSERVATIONAL |
| Enrollment | 130,000 |
| Start date | 28 June 2019 |
| Primary completion | 31 December 2025 |
| Estimated completion | 31 December 2025 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- Non-interventional patient registry
Conditions studied
- Acute Coronary Syndrome — all drugs for Acute Coronary Syndrome →
- Unstable Angina Pectoris — all drugs for Unstable Angina Pectoris →
- Myocardial Infarction — all drugs for Myocardial Infarction →
- Coronary Disease — all drugs for Coronary Disease →
Sponsor
University of Bologna
Who can join
18 and older, any sex, with Acute Coronary Syndrome or Unstable Angina Pectoris. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
ISACS ARCHIVES network is part of ISACS TC (NCT01218776) health care program. It is a collaborative network of research centers that support the rapid development of new scientific information and analytic tools. The ISACS ARCHIVES network assists health care providers, scientists, and policymakers seeking unbiased information about the outcomes, clinical effectiveness, safety, and appropriateness of health care items and services, particularly prescription medications and medical devices in acute coronary syndromes (ACS).
Publications & conference data
8 peer-reviewed publications reference this trial (live from Europe PMC):
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Prior Beta-Blocker Therapy for Hypertension and Sex-Based Differences in Heart Failure Among Patients With Incident Coronary Heart Disease.
Bugiardini R, Yoon J, Kedev S, Stankovic G, et al · · 2020 · cited 25× · PMID 32654558 · DOI 10.1161/hypertensionaha.120.15323 -
Smoking and sex differences in first manifestation of cardiovascular disease.
Vasiljevic Z, Scarpone M, Bergami M, Yoon J, et al · · 2021 · cited 23× · PMID 34233252 · DOI 10.1016/j.atherosclerosis.2021.06.909 -
Sex Differences in Heart Failure Following Acute Coronary Syndromes.
Cenko E, Manfrini O, Yoon J, van der Schaar M, et al · · 2023 · cited 13× · PMID 38939586 · DOI 10.1016/j.jacadv.2023.100294 -
Statins for primary prevention among elderly men and women.
Bergami M, Cenko E, Yoon J, Mendieta G, et al · · 2022 · cited 9× · PMID 34864917 · DOI 10.1093/cvr/cvab348 -
Traditional risk factors and premature acute coronary syndromes in South Eastern Europe: a multinational cohort study.
Bugiardini R, Cenko E, Yoon J, Bergami M, et al · · 2024 · cited 8× · PMID 38476741 · DOI 10.1016/j.lanepe.2023.100824 -
Coronary revascularization and sex differences in cardiovascular mortality after myocardial infarction in 12 high and middle-income European countries.
Cenko E, Yoon J, Bergami M, Gale CP, et al · · 2025 · cited 7× · PMID 38714331 · DOI 10.1093/ehjqcco/qcae035 -
Reduced Heart Failure and Mortality in Patients Receiving Statin Therapy Before Initial Acute Coronary Syndrome.
Bugiardini R, Yoon J, Mendieta G, Kedev S, et al · · 2022 · cited 7× · PMID 35589164 · DOI 10.1016/j.jacc.2022.03.354 -
Concerns about the use of digoxin in acute coronary syndromes.
Bugiardini R, Cenko E, Yoon J, van der Schaar M, et al · · 2022 · cited 6× · PMID 34251454 · DOI 10.1093/ehjcvp/pvab055
Verify or expand the search:
- PubMed search for NCT04008173
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other University of Bologna trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04008173 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Bologna
- Last refreshed: 6 December 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04008173.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing