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NCT04005079: PACCT
Pilocarpine After Combined Cataract/Trabectome Surgery
Phase 3 trial testing Pilocarpine in Open Angle Glaucoma. Withdrawn.
21 January 2021
Quick facts
| Lead sponsor | Montefiore Medical Center |
|---|---|
| Phase | Phase 3 |
| Status | Withdrawn |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Start date | 5 June 2019 |
| Primary completion | 21 January 2021 |
| Estimated completion | 21 January 2021 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Pilocarpine (PILOCARPINE) — full drug profile →
- Ofloxacin (OFLOXACIN) — full drug profile →
- Prednisolone — full drug profile →
Conditions studied
- Open Angle Glaucoma — all drugs for Open Angle Glaucoma →
- Ocular Hypertension — all drugs for Ocular Hypertension →
Sponsor
Montefiore Medical Center
Who can join
Adults 30 to 100, any sex, with Open Angle Glaucoma or Ocular Hypertension. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Combined cataract + trabectome surgery is a surgery designed to help lower the intraocular pressure (pressure in the eye) and hopefully reduce the need for topical drops, progression of glaucoma, and/or further glaucoma surgeries. The purpose of this study is to assess whether using pilocarpine, a medication which is FDA approved to induce miosis, (in other words cause the pupil to constrict or become smaller) provides additional benefit to the success of Trabectome and cataract surgery.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT04005079
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Pilocarpine
Trials testing the same drug.
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- NCT04675151 — Safety and Efficacy of Nyxol With Pilocarpine Eye Drops in Subjects With Presbyopia · Phase 2 · completed
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- NCT02935894 — Investigating the Stability, Variability and Mechanism of Incorporation of Lipid Mediators Into Eccrine Sweat · NA · completed
Other recruiting trials for Open Angle Glaucoma
Currently open trials in the same condition.
- NCT07228221 — Standalone iStent Infinite and iDose TR for Management of Moderate to Severe Open Angle Glaucoma · Phase 4 · recruiting
- NCT06883123 — Efficacy of Simbrinza and Rocklatan vs Cosopt and Latanoprost · Phase 4 · recruiting
- NCT06666855 — A Phase III Study in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension in China · Phase 3 · active not recruiting
- NCT06246136 — Comparative Effectiveness and Safety of ELIOS in Patients With Open-Angle Glaucoma Undergoing Cataract Surgery · NA · recruiting
- NCT06061718 — Travoprost Intraocular Implant in Conjunction With Cataract Surgery · Phase 3 · active not recruiting
Other Montefiore Medical Center trials
Trials by the same sponsor.
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- NCT07076069 — The Effect of Multimodal Pain Regimen on Use of Narcotics After Rotator Cuff Tear Repair · Phase 4 · recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04005079 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Montefiore Medical Center
- Last refreshed: 7 April 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04005079.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing