NCT04002219

Efficacy Evaluation of the Mushroom Beverage on Emotion Regulation

Completed NA Last updated 10 October 2022

What this trial tests

NA trial testing beverage containing mushroom-extracts in Inflammation, Brain in 80 participants. Completed in 28 February 2020.

Timeline

1 July 2019

Primary endpoint
31 December 2019

28 February 2020

Quick facts

Lead sponsor	National Science and Technology Council, Taiwan
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	80
Start date	1 July 2019
Primary completion	31 December 2019
Estimated completion	28 February 2020
Sites	1 location across Taiwan

Drugs / interventions tested

• beverage containing mushroom-extracts

Conditions studied

• Inflammation, Brain — all drugs for Inflammation, Brain →
• Emotional Problem — all drugs for Emotional Problem →

Sponsor

National Science and Technology Council, Taiwan

Who can join

Adults 20 to 65, any sex, with Inflammation, Brain or Emotional Problem. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Major Depression Disorder is one of the most common psychiatric disease and has affecting approximately 350 million people in the world. According to World Health Organization's report, it may be the first burden of disease in 2030. Due to the high morbidity and low acceptance in the treatment, it is necessary to find some nature compounds to prevent the disease.

Cordyceps militaris, one of the most treasure Chinese herbs in Asia, contains many kinds of component such as cordycepin, polysaccharide, mannitol. In winter, it appears as an worm in the soil, afterwards, it grows out of the soil and convert into grass in summer. A previous study has demonstrated that Cordyceps militaris has anti-depressive effect in mouse tail suspension test, and in this study we will explore its effect in human subjects.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Edible Mushrooms as a Potential Component of Dietary Interventions for Major Depressive Disorder.
   Fijałkowska A, Jędrejko K, Sułkowska-Ziaja K, Ziaja M, et al · · 2022 · cited 16× · PMID 35627059 · DOI 10.3390/foods11101489
2. Innovative applications of medicinal mushrooms in functional foods and nutraceuticals: a focus on health-boosting beverages.
   Yang JY, Tao L, Lou D, Patabendige NM, et al · · 2025 · cited 3× · PMID 40909340 · DOI 10.3389/fcimb.2025.1605301