Who is sponsoring NCT04000672?

NCT04000672 is sponsored by Chinese University of Hong Kong.

What drugs are being tested in NCT04000672?

Interventions in NCT04000672: 3D printed patient specific metal jigs (PSI jig), HTO with navigation.

What condition does NCT04000672 study?

NCT04000672 studies Osteotomy, Randomized Controlled Trial.

Is NCT04000672 still recruiting?

NCT04000672 is currently completed. Last updated 7 December 2023.

Last reviewed 2023-12-07 · How we verify

NCT04000672: ProtectedHTO

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Patient Specific Instrumentation (PSI) Referencing Osteotomy Technological Transfer - a Randomized Control Trial (RCT)

Completed NA Last updated 7 December 2023

What this trial tests

NA trial testing 3D printed patient specific metal jigs (PSI jig) in Osteotomy in 40 participants. Completed in 6 December 2023.

Timeline

1 July 2019

Primary endpoint
6 December 2023

6 December 2023

Quick facts

Lead sponsor	Chinese University of Hong Kong
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	40
Start date	1 July 2019
Primary completion	6 December 2023
Estimated completion	6 December 2023
Sites	1 location across Hong Kong

Drugs / interventions tested

3D printed patient specific metal jigs (PSI jig)
HTO with navigation

Conditions studied

Osteotomy — all drugs for Osteotomy →
Randomized Controlled Trial — all drugs for Randomized Controlled Trial →

Sponsor

Chinese University of Hong Kong

Who can join

Adults 18 to 70, any sex, with Osteotomy or Randomized Controlled Trial. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Medial open wedge high tibial osteotomy is a surgery performed to treat knee osteoarthritis in young patients.Recently with our department advance of technology, the investigators performed computed tomography for the patient's lower limb and 3D reconstruct the image. Based on the 3D image, the investigators planned our planned osteotomy cut on computer software Materialize 3 and the investigators then 3D printed a metal jig that has a slot to produce the osteotomy and also protected the neurovascular bundles. Therefore these metal jigs are specific to each patients. The investigators have performed a few cases of HTO under this extra metal jig protection and guidance and noted it has improved accuracy and safety clinically. However, whether it has scientific significance difference in accuracy is not known.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Patient-specific instrumentation (PSI) Referencing High Tibial Osteotomy Technological Transfer and Education: protocol for a double-blind, randomised controlled trial (PROTECTED HTO Trial).
Lau LCM, Chui ECS, Fan JCH, Man GCW, et al · · 2021 · cited 8× · PMID 33550239 · DOI 10.1136/bmjopen-2020-041129

Verify or expand the search:

Other recruiting trials for Osteotomy

Currently open trials in the same condition.

NCT07197658 — Healing After Endodontic Microsurgery Using a Rotary Bur Versus Piezoelectric Unit for Osteotomy and Root Resection · NA · recruiting
NCT05362864 — ZNN Bactiguard Cephalomedullary Nails PMCF Study · active not recruiting

Other Chinese University of Hong Kong trials

Trials by the same sponsor.

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NCT07230457 — Plasma MTB cfDNA Before Bronchoscopy · not yet recruiting
NCT07288671 — Nostalgia Intervention on Alleviating Loneliness Amongst Older Adults · NA · not yet recruiting
NCT07256457 — Postoperative Pulmonary Function Assessment Based on Deep Learning Study · NA · not yet recruiting
NCT06904209 — Can Artificial Intelligence Reduce Consumption of Standard High Volume Bowel Preparation Regimen Among Older Population, · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04000672 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Chinese University of Hong Kong
Last refreshed: 7 December 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04000672.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing