NCT04000490 (SCARE) is a clinical trial of SCARE Score in Assessment, sponsored by Centre Hospitalier Régional d'Orléans.

Who is sponsoring NCT04000490?

NCT04000490 is sponsored by Centre Hospitalier Régional d'Orléans.

What drugs are being tested in NCT04000490?

Interventions in NCT04000490: SCARE Score.

What condition does NCT04000490 study?

NCT04000490 studies Assessment, Chest Pain, ACS - Acute Coronary Syndrome.

Is NCT04000490 still recruiting?

NCT04000490 is currently completed. Last updated 1 September 2020.

Last reviewed 2020-09-01 · How we verify

NCT04000490: SCARE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

External Validation of the SCARE Score

Completed Last updated 1 September 2020

What this trial tests

trial testing SCARE Score in Assessment in 2,205 participants. Completed in 25 March 2020.

Timeline

1 October 2019

Primary endpoint
25 March 2020

25 March 2020

Quick facts

Lead sponsor	Centre Hospitalier Régional d'Orléans
Status	Completed
Study type	OBSERVATIONAL
Enrollment	2,205
Start date	1 October 2019
Primary completion	25 March 2020
Estimated completion	25 March 2020
Sites	4 locations across France

Drugs / interventions tested

SCARE Score

Conditions studied

Assessment — all drugs for Assessment →
Chest Pain — all drugs for Chest Pain →
ACS - Acute Coronary Syndrome — all drugs for ACS - Acute Coronary Syndrome →

Sponsor

Centre Hospitalier Régional d'Orléans

Who can join

18 and older, any sex, with Assessment or Chest Pain. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Chest pain is a very common reason for resorting to the call center. The etiologies are very varied, ranging from benign pathologies to some that may involve, in the short term, the vital prognosis such as Acute Coronary Syndrome (ACS). ACS is a partial or complete occlusion of a coronary artery that causes potentially irreversible myocardial pain unless prompt treatment is undertaken. ACS represents 120 000 cases per year in France and causes about 18 000 deaths. There is currently no support score for the assessment of chest pain. However, reducing the duration of management of ACS is essential in order to hope to reduce the associated morbidity and mortality. In 2016, SAMU45's team established a predictive ACS score for the assessement of chest pain in SAMU 45 (France) based on the prospective study of 1367 patients. Seven items significantly associated with this risk of ACS could be highlighted: age, sex, smoking, typicality (potentially constrictive chest pain radiating potentially to the shoulders and / or jaw) pain, inaugural character of pain (ie first episode of this type), presence of sweats and the physician's belief to be in the presence of an ACS. These seven variables make up the SCARE score. This had good internal discrimination (AUC at 0.81) and excellent calibration ("p" of Hosmer-Lemeshow at 0.74). This score makes it possible to stratify the risk of ACS, by using epidemiological elements but also the physician's belief, whose Negative Predictive Value (VPN) proved excellent. The objective of this new project is to confirm by an external validation via a multicentric study the robustness of this score and thus be able to consider its use in front of any chest pain regulated in France by a call center.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04000490 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Centre Hospitalier Régional d'Orléans
Last refreshed: 1 September 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04000490.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing