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NCT03997552
NIPSA Versus Marginal Approach by Palatal Incision and MIST in Periodontal Regeneration
NA trial testing Non-incised papillae surgical approach (NIPSA) in Periodontitis in 60 participants. Currently enrolling.
1 December 2026
Quick facts
| Lead sponsor | Universidad de Murcia |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 60 |
| Start date | 6 September 2019 |
| Primary completion | 1 December 2026 |
| Estimated completion | 1 February 2027 |
| Sites | 1 location across Spain |
Drugs / interventions tested
- Non-incised papillae surgical approach (NIPSA)
- marginal approach by palatal incision
- Minimally invasive surgical technique (MIST)
Conditions studied
- Periodontitis — all drugs for Periodontitis →
- Periodontal Diseases — all drugs for Periodontal Diseases →
- Periodontal Pocket — all drugs for Periodontal Pocket →
Sponsor
Universidad de Murcia — full company profile →
Who can join
18 and older, any sex, with Periodontitis or Periodontal Diseases. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Three techniques for periodontal reconstruction will be compared, in which marginal access versus apical access will be carried out.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT03997552
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Universidad de Murcia trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03997552 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Universidad de Murcia
- Last refreshed: 17 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03997552.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing