NCT03994640 is a Phase 2, PHASE3 clinical trial of Cannabis Cream in Temporomandibular Disorder, sponsored by Medical University of Silesia.

Who is sponsoring NCT03994640?

NCT03994640 is sponsored by Medical University of Silesia.

What drugs are being tested in NCT03994640?

Interventions in NCT03994640: Cannabis Cream, Placebo Cream.

What condition does NCT03994640 study?

NCT03994640 studies Temporomandibular Disorder, Myofascial Pain, Cannabis, Electromyography.

Is NCT03994640 still recruiting?

NCT03994640 is currently completed. Last updated 21 June 2019.

Last reviewed 2019-06-21 · How we verify

NCT03994640

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Myorelaxant Effect of Cannabis Cream Topical Skin Application in Patients With TMD

Completed Phase 2, PHASE3 Last updated 21 June 2019

What this trial tests

Phase 2, PHASE3 trial testing Cannabis Cream in Temporomandibular Disorder in 20 participants. Completed in 1 January 2019.

Timeline

1 January 2018

Primary endpoint
1 October 2018

1 January 2019

Quick facts

Lead sponsor	Medical University of Silesia
Phase	Phase 2, PHASE3
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	20
Start date	1 January 2018
Primary completion	1 October 2018
Estimated completion	1 January 2019
Sites	1 location across Poland

Drugs / interventions tested

Cannabis Cream
Placebo Cream

Conditions studied

Temporomandibular Disorder — all drugs for Temporomandibular Disorder →
Myofascial Pain — all drugs for Myofascial Pain →
Cannabis — all drugs for Cannabis →
Electromyography — all drugs for Electromyography →

Sponsor

Medical University of Silesia

Who can join

Adults 22 to 27, any sex, with Temporomandibular Disorder or Myofascial Pain. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Evaluation of myorelaxant effect of cannabis cream.compared to placebo cream in topical skin application in patients with TMD

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Myorelaxant Effect of Transdermal Cannabidiol Application in Patients with TMD: A Randomized, Double-Blind Trial.
Nitecka-Buchta A, Nowak-Wachol A, Wachol K, Walczyńska-Dragon K, et al · · 2019 · cited 52× · PMID 31698733 · DOI 10.3390/jcm8111886
Therapeutic Agents for the Treatment of Temporomandibular Joint Disorders: Progress and Perspective.
Wu M, Cai J, Yu Y, Hu S, et al · · 2020 · cited 28× · PMID 33584275 · DOI 10.3389/fphar.2020.596099

Verify or expand the search:

Other recruiting trials for Temporomandibular Disorder

Currently open trials in the same condition.

NCT06941636 — Botulinumtoxin A as a Treatment for Myalgia and Myofacial Pain in Patient With Temporomandibulardisorders · Phase 3 · recruiting
NCT03849534 — Treatment of Temporomandibular Disorders in Children and Adolsecents · NA · recruiting
NCT06214923 — Neural Mechanisms of Immersive Virtual Reality in Chronic Pain (VR TMD EEG) · NA · recruiting
NCT06365151 — An Algorithm for Approaching Temporomandibular Disorders With Osteopathic Manual Therapy in Patients With Fibromyalgia · NA · recruiting
NCT06357702 — K23- Physical Self Regulation vs Placebo · NA · recruiting

Other Medical University of Silesia trials

Trials by the same sponsor.

NCT06212674 — Single-stage Pulmonary Vein Isolation Combined With Percutaneous Left Atrial Appendage Occluder Implantation in Patients · Phase 4 · recruiting
NCT06970002 — Respiratory Stabilization in Chronic Acidosis Before Bronchofiberoscopy & Non-Invasive Ventilation Effectivenes · NA · not yet recruiting
NCT07137299 — POPQ Associated With Total Laparoscopic Hysterectomy · not yet recruiting
NCT06970041 — To Assess the Types of Mechanical Ventilation in Enabling Therapeutic Bronchofiberoscopy in Patients With Decompensated · NA · not yet recruiting
NCT07120529 — Minimally Invasive Surgery Versus Open Radical Hysterectomy in Presumably Early Stage Cervical Cancer: a Retrospective M · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03994640 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Medical University of Silesia
Last refreshed: 21 June 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03994640.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing