NCT03990181 is a NA clinical trial of meal matrix & NPPS in Iron Metabolism Disorders, sponsored by Swiss Federal Institute of Technology.

Who is sponsoring NCT03990181?

NCT03990181 is sponsored by Swiss Federal Institute of Technology.

What drugs are being tested in NCT03990181?

Interventions in NCT03990181: meal matrix & NPPS, meal matrix & CS, no-matrix & NPPS, no-matrix & CS.

What condition does NCT03990181 study?

NCT03990181 studies Iron Metabolism Disorders, Iron Overload, Polyphenols.

Is NCT03990181 still recruiting?

NCT03990181 is currently completed. Last updated 26 May 2021.

Last reviewed 2021-05-26 · How we verify

NCT03990181

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Inhibiting Dietary Iron Absorption in Subjects With Hereditary Hemochromatosis by a Natural Polyphenol Supplement

Completed NA Last updated 26 May 2021

What this trial tests

NA trial testing meal matrix & NPPS in Iron Metabolism Disorders in 14 participants. Completed in 15 August 2020.

Timeline

20 September 2019

Primary endpoint
15 August 2020

15 August 2020

Quick facts

Lead sponsor	Swiss Federal Institute of Technology
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	single
Primary purpose	basic science
Enrollment	14
Start date	20 September 2019
Primary completion	15 August 2020
Estimated completion	15 August 2020
Sites	2 locations across Portugal, Switzerland

Drugs / interventions tested

meal matrix & NPPS
meal matrix & CS
no-matrix & NPPS
no-matrix & CS

Conditions studied

Iron Metabolism Disorders — all drugs for Iron Metabolism Disorders →
Iron Overload — all drugs for Iron Overload →
Polyphenols — all drugs for Polyphenols →

Sponsor

Swiss Federal Institute of Technology

Who can join

Adults 18 to 65, any sex, with Iron Metabolism Disorders or Iron Overload. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Polyphenolic compounds are very strong Inhibitors of non-heme iron absorption, as they form insoluble complexes with ferrous iron. Patients with hereditary hemochromatosis (HH) have an increased intestinal non-heme iron absorption due to a genetic mutation in the regulatory pathway, leading to excess iron in the body. This study investigates the inhibitory effect of a natural polyphenol Supplement in participants with HH.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

The Role of Iron in Benign and Malignant Hematopoiesis.
Sinha S, Pereira-Reis J, Guerra A, Rivella S, et al · · 2021 · cited 18× · PMID 33231101 · DOI 10.1089/ars.2020.8155
The effect of a natural polyphenol supplement on iron absorption in adults with hereditary hemochromatosis.
Buerkli S, Salvioni L, Koller N, Zeder C, et al · · 2022 · cited 12× · PMID 35320401 · DOI 10.1007/s00394-022-02829-8

Verify or expand the search:

Other recruiting trials for Iron Metabolism Disorders

Currently open trials in the same condition.

NCT05586867 — Study of Markers of Iron Metabolism and Their Relationship With Phosphocalcic and Hepatic Metabolism and Inflammation in · recruiting
NCT04008147 — Hepcidin and Glucose Metabolism · NA · recruiting

Other Swiss Federal Institute of Technology trials

Trials by the same sponsor.

NCT07182734 — Feasibility of Unsupervised Therapy After Neurological or Orthopaedical Injury in the Home Setting With a Hand Rehabilit · NA · not yet recruiting
NCT06725784 — Feasibility and Cost of Robot-assisted Upper Limb Rehabilitation with Different Levels of Supervision · NA · recruiting
NCT06851130 — Assessing the Immediate Increase in Serum Ferritin After Oral Iron Doses: an Experimental Study in Iron-deficient Women · NA · recruiting
NCT06149975 — Feasibility of a Motor-cognitive Training Program in Patients With Traumatic Brain Injury · NA · completed
NCT06116669 — Effects of Oral Iron Supplementation Before vs at Time of Vaccination on Immune Response in Iron Deficient Kenyan Women · NA · unknown

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03990181 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Swiss Federal Institute of Technology
Last refreshed: 26 May 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03990181.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing