NCT03987932

NEAT!2 Sedentary Behavior Reduction for Individuals With Past or Present Knee Symptoms, Injuries, or Surgeries

Terminated NA Results posted Last updated 19 July 2021

What this trial tests

NA trial testing NEAT!2 in Sedentary Lifestyle in 11 participants. Terminated before completion.

Timeline

22 June 2019

Primary endpoint
9 September 2020

9 September 2020

Quick facts

Lead sponsor	University of South Carolina
Phase	NA
Status	Terminated
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	11
Start date	22 June 2019
Primary completion	9 September 2020
Estimated completion	9 September 2020
Sites	1 location across United States

Drugs / interventions tested

• NEAT!2
• NEAT!2+Calls
• Delayed NEAT!2

Conditions studied

• Sedentary Lifestyle — all drugs for Sedentary Lifestyle →
• Knee Osteoarthritis — all drugs for Knee Osteoarthritis →
• Knee Injuries — all drugs for Knee Injuries →
• Knee Pain Chronic — all drugs for Knee Pain Chronic →

Sponsor

University of South Carolina

Who can join

40 and older, any sex, with Sedentary Lifestyle or Knee Osteoarthritis. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Change in Sedentary Behavior at 1 Month Primary · Baseline to 1 month

Daily sedentary behavior objectively measured by activpal

Group	Value	95% CI
NEAT!2	-33.7	± 119.2
NEAT!2+Calls	-24.5	± 23.0
Delayed NEAT!2	32.0	± 44.2

Change in Sedentary Behavior at 3 Months Primary · Baseline to 3 months

Daily sedentary behavior objectively measured by activpal

Group	Value	95% CI
NEAT!2	43.4	± 99.1
NEAT!2+Calls	-44.7	± 39.4
Delayed NEAT!2	12.9	± 14.3

Change in Timed Up & Go at 1 Month Secondary · Baseline to 1 month

Physical function assessed by Timed Up \& Go (seconds)

Group	Value	95% CI
NEAT!2	-.4	± 1.0
NEAT!2+Calls	-.4	± 1.5
Delayed NEAT!2	-.1	± 1.0

Change in Chair Stands at 1 Month Secondary · Baseline to 1 month

Physical function assessed by Chair Stand Test (# stands in 30 seconds)

Group	Value	95% CI
NEAT!2	.3	± 1.2
NEAT!2+Calls	2	± 1.4
Delayed NEAT!2	.3	± 1.2

Change in 6 Minute Walk at 1 Month Secondary · Baseline to 1 month

Physical function assessed by 6 minute walk (total feet)

Group	Value	95% CI
NEAT!2	76.0	± 130.7
NEAT!2+Calls	74	± 104.7
Delayed NEAT!2	89.0	± 123.1

Change in Timed Up & Go at 3 Months Secondary · Baseline to 3 months

Physical function assessed by Timed Up \& Go (seconds)

Group	Value	95% CI
NEAT!2	-.3	± 1.4
NEAT!2+Calls	-1.1	± 1.0
Delayed NEAT!2	-.6	± .7

Change in Chair Stands at 3 Months Secondary · Baseline to 3 months

Physical function assessed by Chair Stand Test (# stands in 30 seconds)

Group	Value	95% CI
NEAT!2	2.3	± .6
NEAT!2+Calls	3.0	± 2.8
Delayed NEAT!2	-.7	± 2.9

Change in 6 Minute Walk at 3 Months Secondary · Baseline to 3 months

Physical function assessed by 6 minute walk (total feet)

Group	Value	95% CI
NEAT!2	15.5	± 11.4
NEAT!2+Calls	678.2	± 525.8
Delayed NEAT!2	75.1	± 81.9

Maintenance of Changes in Sedentary Behavior at 6 Months Secondary · Baseline to 6 months

Daily sedentary behavior objectively measured by activpal

Group	Value	95% CI
NEAT!2	-30.5	± 90.9
NEAT!2+Calls	-84.4	± 138.3
Delayed NEAT!2	80.2	± 10.8

Sponsor's own description

This study will evaluate the effectiveness of an mHealth sedentary reduction program over a 6-month period of time in adults with past or present knee symptoms, injuries, or surgeries.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.