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NCT03986476
The Effect of Two Probiotic Products on the Intestinal Barrier Function in Patients With Irritable Bowel Syndrome
NA trial testing Probiotics in IBS in 65 participants. Completed in 10 May 2021.
10 May 2021
Quick facts
| Lead sponsor | Örebro University, Sweden |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | basic science |
| Enrollment | 65 |
| Start date | 26 March 2019 |
| Primary completion | 10 May 2021 |
| Estimated completion | 10 May 2021 |
| Sites | 1 location across Sweden |
Drugs / interventions tested
- Probiotics — full drug profile →
- Placebo
Conditions studied
- IBS — all drugs for IBS →
Sponsor
Örebro University, Sweden
Who can join
Adults 18 to 65, any sex, with IBS. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study will investigate the effects of supplementation with two different probiotic products (Lactobacillus reuteri strains) on the intestinal barrier function, gut health and stress symptoms in diarrhoea-predominant irritable bowel syndrome (IBS-D) patients.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The effects of a 6-week intervention with Limosilactobacillus reuteri ATCC PTA 6475 alone and in combination with L. reuteri DSM 17938 on gut barrier function, immune markers, and symptoms in patients with IBS-D-An exploratory RCT.
König J, Roca Rubio MF, Forsgård RA, Rode J, et al · · 2024 · cited 5× · PMID 39485760 · DOI 10.1371/journal.pone.0312464
Verify or expand the search:
- PubMed search for NCT03986476
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for IBS
Currently open trials in the same condition.
- NCT06275906 — Influence of a Mediterranean Diet Combined With a Physical Activity Intervention, on NAFLD and Inflammation Parameters. · NA · recruiting
- NCT05815602 — Ebastine Versus Mebeverine in IBS Patients · Phase 3 · recruiting
Other Örebro University, Sweden trials
Trials by the same sponsor.
- NCT07521709 — Evaluation of an Online ACT and Compassion-based Intervention for Disorders of Gut-Brain Interaction · NA · not yet recruiting
- NCT07350239 — Clinical, Microbial and Tissue-based Characterization of Patients Treated for Severe Temporomandibular Joint Pathology · not yet recruiting
- NCT07527793 — Monitoring Changes in Blood Circulating Metabolites Using Minimally Invasive Techniques · NA · recruiting
- NCT07175402 — Feasibility and Acceptability of an Online ACT Intervention for Disorders of Gut-Brain Interaction - Beta Trial · NA · completed
- NCT06887751 — Feasibility and Acceptability of an Online ACT Intervention for Disorders of Gut-Brain Interaction · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03986476 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Örebro University, Sweden
- Last refreshed: 9 September 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03986476.
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