NCT03979872 (RISE-UP) is a NA clinical trial of MC1R Genetic Testing in Melanoma, sponsored by University of Utah.

Who is sponsoring NCT03979872?

NCT03979872 is sponsored by University of Utah.

What drugs are being tested in NCT03979872?

Interventions in NCT03979872: MC1R Genetic Testing, Skin Cancer Education, UV Photo.

What condition does NCT03979872 study?

NCT03979872 studies Melanoma, Young Adult.

Is NCT03979872 still recruiting?

NCT03979872 is currently completed. Last updated 13 July 2021.

Are results published for NCT03979872?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2021-07-13 · How we verify

NCT03979872: RISE-UP

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Risk Information and Skin-cancer Education for Undergraduate Prevention

Completed NA Results posted Last updated 13 July 2021

What this trial tests

NA trial testing MC1R Genetic Testing in Melanoma in 92 participants. Completed in 1 August 2020.

Timeline

9 September 2019

Primary endpoint
7 April 2020

1 August 2020

Quick facts

Lead sponsor	University of Utah
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	prevention
Enrollment	92
Start date	9 September 2019
Primary completion	7 April 2020
Estimated completion	1 August 2020
Sites	1 location across United States

Drugs / interventions tested

MC1R Genetic Testing
Skin Cancer Education
UV Photo

Conditions studied

Melanoma — all drugs for Melanoma →
Young Adult — all drugs for Young Adult →

Sponsor

University of Utah

Who can join

18 and older, any sex, with Melanoma or Young Adult. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Sun Protection Behaviors Assessed Via Questionnaires Primary · Weeks 0 (Visit 1), 4 (Visit 2), 8 (Visit 3)

Mean and standard deviation for each sun protection behavior at Visit 1 (baseline), Visit 2 (4 weeks), Visit 3 (8 weeks). "These next questions ask about what you have done in the past four weeks if you were outdoors in the sun for 15 minutes or more. How often did you... " Minimum value =1; Maximum value= 5; Higher scores indicate that participants were more likely to engage in sun protection habits.

Sun Protection- Sunscreen Visit 1

Group	Value	95% CI
Arm 1: Skin Cancer Education Only	2.4	± 1.2
Arm 2: Skin Cancer Education + UV Photo	3.0	± 1.2
Arm 3: Skin Cancer Education + MC1R Testing	2.8	± 1.3
Arm 4: Skin Cancer Education + UV Photo + MC1R Testing	2.3	± 1.1

Sun Protection- Sunscreen Visit 2

Group	Value	95% CI
Arm 1: Skin Cancer Education Only	2.4	± 1.0
Arm 2: Skin Cancer Education + UV Photo	2.4	± 1.4
Arm 3: Skin Cancer Education + MC1R Testing	2.7	± 1.4
Arm 4: Skin Cancer Education + UV Photo + MC1R Testing	2.1	± 1.2

Sun Protection- Sunscreen Visit 3

Group	Value	95% CI
Arm 1: Skin Cancer Education Only	2.3	± 1.3
Arm 2: Skin Cancer Education + UV Photo	2.9	± 1.2
Arm 3: Skin Cancer Education + MC1R Testing	2.3	± 1.6
Arm 4: Skin Cancer Education + UV Photo + MC1R Testing	2.2	± 1.1

Sun Protection- Reapply sunscreen Visit 1

Group	Value	95% CI
Arm 1: Skin Cancer Education Only	1.6	± 1.0
Arm 2: Skin Cancer Education + UV Photo	1.9	± 1.0
Arm 3: Skin Cancer Education + MC1R Testing	2.0	± 1.1
Arm 4: Skin Cancer Education + UV Photo + MC1R Testing	1.9	± 0.8

Sun Protection- Reapply sunscreen Visit 2

Group	Value	95% CI
Arm 1: Skin Cancer Education Only	1.6	± 1.1
Arm 2: Skin Cancer Education + UV Photo	1.6	± 0.9
Arm 3: Skin Cancer Education + MC1R Testing	1.8	± 1.1
Arm 4: Skin Cancer Education + UV Photo + MC1R Testing	1.3	± 0.6

Sun Protection- Reapply sunscreen Visit 3

Group	Value	95% CI
Arm 1: Skin Cancer Education Only	2.2	± 1.1
Arm 2: Skin Cancer Education + UV Photo	1.5	± 1.0
Arm 3: Skin Cancer Education + MC1R Testing	1.7	± 1.1
Arm 4: Skin Cancer Education + UV Photo + MC1R Testing	1.6	± 1.0

Sun Protection- Shirt with sleeves Visit 1

Group	Value	95% CI
Arm 1: Skin Cancer Education Only	3.9	± 1.1
Arm 2: Skin Cancer Education + UV Photo	4.0	± 0.9
Arm 3: Skin Cancer Education + MC1R Testing	4.0	± 0.9
Arm 4: Skin Cancer Education + UV Photo + MC1R Testing	3.6	± 1.5

Sun Protection- Shirt with sleeves Visit 2

Group	Value	95% CI
Arm 1: Skin Cancer Education Only	3.8	± 1.2
Arm 2: Skin Cancer Education + UV Photo	3.9	± 1.5
Arm 3: Skin Cancer Education + MC1R Testing	4.1	± 1.1
Arm 4: Skin Cancer Education + UV Photo + MC1R Testing	4.1	± 1.0

Sunburn Occurrence Assessed Via Questionnaire Secondary · Weeks 0 (Visit 1), 4 (Visit 2), 8 (Visit 3)

Average number of sunburns received by participants in the past 4 weeks when asked at Visit 1 (baseline), Visit 2 (4 weeks), and Visit 3 (8 weeks)

Visit 1

Group	Value	95% CI
Arm 1: Skin Cancer Education Only	1.14	± .468
Arm 2: Skin Cancer Education + UV Photo	1.30	± .559
Arm 3: Skin Cancer Education + MC1R Testing	1.38	± .875
Arm 4: Skin Cancer Education + UV Photo + MC1R Testing	1.13	± .458

Visit 2

Group	Value	95% CI
Arm 1: Skin Cancer Education Only	1.50	± 1.192
Arm 2: Skin Cancer Education + UV Photo	1.25	± .716
Arm 3: Skin Cancer Education + MC1R Testing	1.23	± .528
Arm 4: Skin Cancer Education + UV Photo + MC1R Testing	1.05	± .213

Visit 3

Group	Value	95% CI
Arm 1: Skin Cancer Education Only	1.63	± 1.300
Arm 2: Skin Cancer Education + UV Photo	1.67	± 1.175
Arm 3: Skin Cancer Education + MC1R Testing	1.06	± .236
Arm 4: Skin Cancer Education + UV Photo + MC1R Testing	1.16	± .501

Intentional Outdoor Tanning Occurrence Assessed Via Questionnaire Secondary · Weeks 0 (Visit 1), 4 (Visit 2), 8 (Visit 3)

Mean and standard deviation for intentional outdoor tanning occurrences at Visit 1 (baseline), Visit 2 (4 weeks), Visit 3 (8 weeks). "In the past 4 Weeks, how often did you spend time in the sun in order to get tan?" Minimum value =1; Maximum value= 5; Higher scores indicates that participants spent more time outdoors to get a tan.

Visit 1

Group	Value	95% CI
Arm 1: Skin Cancer Education Only	1.8	± 1.1
Arm 2: Skin Cancer Education + UV Photo	1.4	± 0.8
Arm 3: Skin Cancer Education + MC1R Testing	1.5	± 1.1
Arm 4: Skin Cancer Education + UV Photo + MC1R Testing	1.6	± 0.9

Visit 2

Group	Value	95% CI
Arm 1: Skin Cancer Education Only	1.4	± 0.8
Arm 2: Skin Cancer Education + UV Photo	1.2	± 0.5
Arm 3: Skin Cancer Education + MC1R Testing	1.4	± 0.7
Arm 4: Skin Cancer Education + UV Photo + MC1R Testing	1.4	± 0.9

Visit 3

Group	Value	95% CI
Arm 1: Skin Cancer Education Only	1.7	± 1.2
Arm 2: Skin Cancer Education + UV Photo	1.3	± 0.8
Arm 3: Skin Cancer Education + MC1R Testing	1.1	± 0.5
Arm 4: Skin Cancer Education + UV Photo + MC1R Testing	1.5	± 0.8

Intentional Indoor Tanning Occurrence Assessed Via Questionnaire Secondary · Weeks 0 (Visit 1), 4 (Visit 2), 8 (Visit 3)

Number of times participant used an indoor tanning device in the past 4 weeks when asked at Visit 1 (baseline), Visit 2 (4 weeks), and Visit 3 (8 weeks)

Visit 1

Group	Value	95% CI
Arm 1: Skin Cancer Education Only	22
Arm 2: Skin Cancer Education + UV Photo	23
Arm 3: Skin Cancer Education + MC1R Testing	24
Arm 4: Skin Cancer Education + UV Photo + MC1R Testing	23
Arm 1: Skin Cancer Education Only	0
Arm 2: Skin Cancer Education + UV Photo	0
Arm 3: Skin Cancer Education + MC1R Testing	0
Arm 4: Skin Cancer Education + UV Photo + MC1R Testing	0
Arm 1: Skin Cancer Education Only	0
Arm 2: Skin Cancer Education + UV Photo	0
Arm 3: Skin Cancer Education + MC1R Testing	0
Arm 4: Skin Cancer Education + UV Photo + MC1R Testing	0
Arm 1: Skin Cancer Education Only	0
Arm 2: Skin Cancer Education + UV Photo	0
Arm 3: Skin Cancer Education + MC1R Testing	0
Arm 4: Skin Cancer Education + UV Photo + MC1R Testing	0

Visit 2

Group	Value	95% CI
Arm 1: Skin Cancer Education Only	19
Arm 2: Skin Cancer Education + UV Photo	19
Arm 3: Skin Cancer Education + MC1R Testing	22
Arm 4: Skin Cancer Education + UV Photo + MC1R Testing	21
Arm 1: Skin Cancer Education Only	0
Arm 2: Skin Cancer Education + UV Photo	1
Arm 3: Skin Cancer Education + MC1R Testing	0
Arm 4: Skin Cancer Education + UV Photo + MC1R Testing	0
Arm 1: Skin Cancer Education Only	0
Arm 2: Skin Cancer Education + UV Photo	0
Arm 3: Skin Cancer Education + MC1R Testing	0
Arm 4: Skin Cancer Education + UV Photo + MC1R Testing	1
Arm 1: Skin Cancer Education Only	1
Arm 2: Skin Cancer Education + UV Photo	0
Arm 3: Skin Cancer Education + MC1R Testing	0
Arm 4: Skin Cancer Education + UV Photo + MC1R Testing	0

Visit 3

Group	Value	95% CI
Arm 1: Skin Cancer Education Only	17
Arm 2: Skin Cancer Education + UV Photo	13
Arm 3: Skin Cancer Education + MC1R Testing	18
Arm 4: Skin Cancer Education + UV Photo + MC1R Testing	17
Arm 1: Skin Cancer Education Only	1
Arm 2: Skin Cancer Education + UV Photo	1
Arm 3: Skin Cancer Education + MC1R Testing	0
Arm 4: Skin Cancer Education + UV Photo + MC1R Testing	1
Arm 1: Skin Cancer Education Only	0
Arm 2: Skin Cancer Education + UV Photo	1
Arm 3: Skin Cancer Education + MC1R Testing	0
Arm 4: Skin Cancer Education + UV Photo + MC1R Testing	1
Arm 1: Skin Cancer Education Only	1
Arm 2: Skin Cancer Education + UV Photo	0
Arm 3: Skin Cancer Education + MC1R Testing	0
Arm 4: Skin Cancer Education + UV Photo + MC1R Testing	0

Tan Occurrence Assessed Via Questionnaire Secondary · Weeks 0 (Visit 1), 4 (Visit 2), 8 (Visit 3)

Mean and standard deviation for tan occurrence at Visit 1 (baseline), Visit 2 (4 weeks), Visit 3 (8 weeks). "In the past 4 weeks, how often did you end up with a tan, even if you didn't try to get one?" Minimum value =1; Maximum value= 5; Higher scores indicate that participants received a tan as a result or being outdoors or using an indoor tanning device whether intentional or not.

Visit 1

Group	Value	95% CI
Arm 1: Skin Cancer Education Only	2.3	± 1.2
Arm 2: Skin Cancer Education + UV Photo	2.0	± 1.9
Arm 3: Skin Cancer Education + MC1R Testing	2.1	± 1.3
Arm 4: Skin Cancer Education + UV Photo + MC1R Testing	2.0	± 1.0

Visit 2

Group	Value	95% CI
Arm 1: Skin Cancer Education Only	1.8	± 1.1
Arm 2: Skin Cancer Education + UV Photo	1.6	± 1.0
Arm 3: Skin Cancer Education + MC1R Testing	1.8	± 1.3
Arm 4: Skin Cancer Education + UV Photo + MC1R Testing	1.7	± 1.0

Visit 3

Group	Value	95% CI
Arm 1: Skin Cancer Education Only	1.9	± 1.1
Arm 2: Skin Cancer Education + UV Photo	1.2	± 0.6
Arm 3: Skin Cancer Education + MC1R Testing	1.2	± 0.4
Arm 4: Skin Cancer Education + UV Photo + MC1R Testing	1.6	± 1.0

Sponsor's own description

The purpose of this study will be to provide undergraduate students information about skin cancer risk and prevention. The study will last between 2-3 months. Everyone in the study will be asked to answer questionnaires and receive education about skin cancer risk factors and prevention. We will follow-up with participants by phone, text messages or e-mail in between study visits Participants will be randomly assigned to one of four groups, the group will be in is decided by chance. Participant will either be assigned to: * A group that gets advice about what causes skin cancer and how to prevent it * A group that gets this advice and provides a saliva sample to receive personalized skin cancer risk genetic testing results * A group that gets this advice and receives a personalized photo that shows existing skin damage * A group that gets this advice, receives genetic testing results, and receives a personalized photo.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Increasing Skin Cancer Prevention in Young Adults: the Cumulative Impact of Personalized UV Photography and MC1R Genetic Testing.
Wu YP, Hamilton JG, Kaphingst KA, Jensen JD, et al · · 2023 · cited 9× · PMID 36306029 · DOI 10.1007/s13187-022-02232-1

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03979872 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Utah
Last refreshed: 13 July 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03979872.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing

NCT03979872: RISE-UP

Quick facts

Drugs / interventions tested

Conditions studied

Sponsor

Who can join

Results — posted to ClinicalTrials.gov

Sponsor's own description

Publications & conference data

Related trials

Other recruiting trials for Melanoma

Other University of Utah trials

Verify against primary sources