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NCT03977740

Chest PNF on Pulmonary Function in Parkinson Disease

Status unknown NA Last updated 6 June 2019
What this trial tests

NA trial testing chest PNF in Parkinson Disease in 20 participants. Status unknown.

Timeline
1 January 2018
Primary endpoint
10 June 2019
10 June 2019

Quick facts

Lead sponsorSubhasish Chatterjee
PhaseNA
StatusStatus unknown
Study typeINTERVENTIONAL
Allocationrandomized
Designsequential
Maskingdouble
Primary purposetreatment
Enrollment20
Start date1 January 2018
Primary completion10 June 2019
Estimated completion10 June 2019
Sites1 location across India

Drugs / interventions tested

Conditions studied

Sponsor

Subhasish Chatterjee

Who can join

Adults 50 to 70, any sex, with Parkinson Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Background: Parkinson disease (PD) is a progressive neurodegenerative disorder and characterized by tremor, rigidity and bradykinesia. Almost 84% of PD patient develops respiratory abnormalities and pointed as the most common cause of death. Airway obstruction, trunk muscle rigidity is the common cause of respiratory abnormalities. Purpose: The main purpose of the study will evaluate the efficacy of chest PNF on pulmonary function and chest wall mobility in PD. Methods: 20 participants will be recruited for study purpose and divide into two groups. Group= A will be the control group and participants will receive conventional treatment which includes deep breathing exercise and segmental breathing exercise, incentive spirometry etc for one week. Group= B participants will receive chest PNF exercise along with conventional treatment for a week. Pretreatment and post-treatment data will be recorded by the help of PFT (FVC, FEV1 \& FEV1/FVC) and chest wall expansion at axillary and xiphisternal level for data analysis. Data analysis will be done by paired t-test for within group and independent t-test will be used for the between-group variable. The level of significance will be set at 0.05.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

  1. Microtubule acetylation dyshomeostasis in Parkinson's disease.
    Naren P, Samim KS, Tryphena KP, Vora LK, et al · · 2023 · cited 41× · PMID 37150812 · DOI 10.1186/s40035-023-00354-0

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