NCT03975959: PROMESSE

Memory Perception Assessment in Central/Non-central Nervous System Cancers

Completed NA Last updated 23 September 2025

What this trial tests

NA trial testing QMRP questionnaire in Glioblastoma in 426 participants. Completed in 31 October 2024.

Timeline

10 May 2019

Primary endpoint
27 June 2024

31 October 2024

Quick facts

Lead sponsor	Institut du Cancer de Montpellier - Val d'Aurelle
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	factorial
Masking	none
Primary purpose	supportive care
Enrollment	426
Start date	10 May 2019
Primary completion	27 June 2024
Estimated completion	31 October 2024
Sites	6 locations across France

Drugs / interventions tested

• QMRP questionnaire

Conditions studied

• Glioblastoma — all drugs for Glioblastoma →
• Glioma — all drugs for Glioma →
• Breast Cancer — all drugs for Breast Cancer →
• Healthy — all drugs for Healthy →

Sponsor

Institut du Cancer de Montpellier - Val d'Aurelle — full company profile →

Who can join

Adults 18 to 80, any sex, with Glioblastoma or Glioma. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Prospective memory (PM) is the ability to implement intended actions in the future. It allows maintaining and retrieving future plans, goals, and activities (i.e., remember to remember). PM is associated with most everyday memory problems . PM is crucial to correctly respond to all the social, occupational and working demands of everyday life, to perform many deferred health-related actions and is involved in therapeutic adherence .

Indeed, PM errors are an important part of the aging memory complaints. The prevalence of self-reported PM failures is also significant among young adults, compared with self-reported retrospective memory (RM) failures .Yet, PM errors are major sources of frustration and embarrassment .

In oncology, recently investigated the self-reported memory complaints in a 80 case-healthy-control study breast patients . Subjective memory complaints were assessed using the Prospective and Retrospective Memory Questionnaire . Results from the Paquet et al. study show that all participants (i.e., both patients and matched-controls) reported more PM than RM failures in daily-life (p\<.001). Breast cancer patients reported more RM and PM failures than controls. However, this group effect was no longer statistically significant when controlling for depression and fatigue.

These findings are consistent with the view that memory complaints are closely associated with depression and cancer-related fatigue, and more generally with psychopathological variables .As underlined by Paquet et al. subjective memory complaints should be investigated because they refer to some aspects of the cancer experience that could potentially be linked to quality of life. Thus, it is important to explore psychopathological basis such as depression, anxiety and fatigue while investigating self-reported memory failures in cancer patients.

Despites the importance of PM, there have been, to our knowledge, only few studies evaluating PM complaints or PM functioning in patients diagnosed with an intracerebral tumor (such as Diffuse Low-Grade Glioma- DLGG- or glioblastome- GB) or extra-cerebral tumor (such as breast cancer - BC). Therefore, the investigators thought it would be useful, as a first step, to conduct a study to explore and to manage the PM and RM subjective complaints in cancer patients compared to another chronic disease, such as HIV. In fine, these data will help to identify a new target for psychological management focused on either psychopathological or neuropsychological rehabilitation

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.