NCT03975348

Ventilation Distribution After Bariatric Surgery

Completed NA Last updated 30 July 2020

What this trial tests

NA trial testing High flow nasal cannula in Bariatric Surgery Candidate in 15 participants. Completed in 30 September 2019.

Timeline

15 April 2019

Primary endpoint
30 September 2019

30 September 2019

Quick facts

Lead sponsor	University of Trieste
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	crossover
Masking	none
Primary purpose	treatment
Enrollment	15
Start date	15 April 2019
Primary completion	30 September 2019
Estimated completion	30 September 2019
Sites	1 location across Italy

Drugs / interventions tested

• High flow nasal cannula
• Continuous positive airway pressure
• Facemask

Conditions studied

• Bariatric Surgery Candidate — all drugs for Bariatric Surgery Candidate →
• Atelectasis, Postoperative Pulmonary — all drugs for Atelectasis, Postoperative Pulmonary →

Sponsor

University of Trieste

Who can join

18 and older, any sex, with Bariatric Surgery Candidate or Atelectasis, Postoperative Pulmonary. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Obese patients have an increased risk of developing post-operative respiratory complications due to their comorbidities. They have a restrictive ventilatory defect with reduction of lung volumes and expiratory flow limitation, higher airway resistance and collapsibility of the upper respiratory tract. These abnormalities are worsened by general anesthesia and opioid administration. It has been proved that oxygen therapy with HFNC (high flow nasal cannula) increases lung volumes through a continuous positive airway pressure (CPAP)-effect. This also improves gas exchange and decreases anatomical dead space. At the present time, CPAP represents the gold standard for the prevention of postoperative pulmonary complications. The purpose of this study is to evaluate lung ventilation, gas exchange and comfort with HFNC compared with CPAP during the post-operative period in patients who undergo laparoscopic bariatric surgery.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Lung Volume and Ventilation Distribution After Bariatric Surgery: High-Flow Nasal Cannula Versus CPAP.
   Lena E, Comuzzi L, Ajčević M, Tarchini M, et al · · 2024 · PMID 38744475 · DOI 10.4187/respcare.11356