NCT03974529

Intensive Running Exercise Improves Parkinson's Motor and Non-motor Symptoms

Status unknown NA Last updated 5 June 2019

What this trial tests

NA trial testing Intensive running in Parkinson Disease in 30 participants. Status unknown.

Timeline

29 December 2018

Primary endpoint
30 June 2020

30 December 2020

Quick facts

Lead sponsor	Chinese University of Hong Kong
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	30
Start date	29 December 2018
Primary completion	30 June 2020
Estimated completion	30 December 2020
Sites	1 location across Hong Kong

Drugs / interventions tested

• Intensive running
• Physiotherapy — full drug profile →

Conditions studied

• Parkinson Disease — all drugs for Parkinson Disease →

Sponsor

Chinese University of Hong Kong

Who can join

Adults 40 to 60, any sex, with Parkinson Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

High quality clinical trial and meta-analysis have demonstrated short term, and to a lesser extent, long term benefits in various outcome measures. To achieve positive effects, supervised progressive strength and aerobic endurance training program of 12 weeks was required. Extended progressive strength training improved muscle strength for up to 24 months. While aerobic endurance training would increase walking capacity up to 16 months. 1 There are data suggesting a threshold of intensity of exercise to be reached for the positive effect. This overall body of evidence suggests that regular vigorous exercise should be accorded a central place in the treatment of Parkinson's disease.

However, there was no evidence about regular intensive exercise of running in Parkinson's disease. And most of the studies were not randomized with a control group.

In this study, the investigators are to investigate the effect of regular vigorous aerobic exercise training of running on motor and non-motor symptoms, and quality-of-life of people with Parkinson's disease.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis.
   Ernst M, Folkerts AK, Gollan R, Lieker E, et al · · 2023 · cited 110× · PMID 36602886 · DOI 10.1002/14651858.cd013856.pub2
2. Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis.
   Ernst M, Folkerts AK, Gollan R, Lieker E, et al · · 2024 · cited 37× · PMID 38588457 · DOI 10.1002/14651858.cd013856.pub3